Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models

Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine fo...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2013-09, Vol.73 (17), p.5315-5319
Main Authors: SIOLAS, Despina, HANNON, Gregory J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Cell Transformation, Neoplastic - pathology
Disease Models, Animal
Humans
Medical sciences
Mice
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms - pathology
Pharmacology. Drug treatments
Precision Medicine
Tumors
Xenograft Model Antitumor Assays
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Summary:Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-13-1069