Assessing the role of IL-35 in colorectal cancer progression and prognosis

Despite the recent realization of Interleukin (IL)-35 in tumorigenesis, its exact impact on colorectal cancer (CRC) progression and prognosis, however, is yet to be elucidated clearly. We thus in the present report conducted comparative analysis of IL-35 levels between CRC patients and matched contr...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2013-01, Vol.6 (9), p.1806-1816
Main Authors: Zeng, Jin-Cheng, Zhang, Zhi, Li, Tian-Yu, Liang, Yan-Fang, Wang, Hong-Mei, Bao, Jing-Jing, Zhang, Jun-Ai, Wang, Wan-Dang, Xiang, Wen-Yu, Kong, Bin, Wang, Zhi-Yong, Wu, Bin-Hua, Chen, Xiao-Dong, He, Long, Zhang, Shu, Wang, Cong-Yi, Xu, Jun-Fa
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Adult
Aged
Biomarkers, Tumor - blood
Biomarkers, Tumor - metabolism
Case-Control Studies
Cell Cycle Proteins - metabolism
Chemotaxis, Leukocyte
Colectomy
Colorectal Neoplasms - blood
Colorectal Neoplasms - immunology
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Disease Progression
Female
Humans
Interleukins - blood
Interleukins - metabolism
Lymphocytes, Tumor-Infiltrating - immunology
Lymphocytes, Tumor-Infiltrating - metabolism
Male
Middle Aged
Minor Histocompatibility Antigens
Neoplasm Grading
Neoplasm Staging
Original
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Treatment Outcome
Tumor Microenvironment
Young Adult
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Summary:Despite the recent realization of Interleukin (IL)-35 in tumorigenesis, its exact impact on colorectal cancer (CRC) progression and prognosis, however, is yet to be elucidated clearly. We thus in the present report conducted comparative analysis of IL-35 levels between CRC patients and matched control subjects. IL-35 is highly expressed in all CRC tissues, which can be detected in vast majority of colorectal cancer cells. IL-35 levels in CRC lysates and serum samples are highly correlated to the severity of malignancy and the clinical stage of tumor. Particularly, a significant reduction for serum IL-35 was noted in patients after surgical resection, indicating that IL-35 promotes CRC progression associated with poor prognosis. Mechanistic study demonstrated a significant correlation between serum IL-35 levels and the number of peripheral regulatory T (Treg) cells in CRC patients, suggesting that IL-35 implicates in CRC pathogenesis probably by inducing Treg cells, while cancer cell-derived IL-35 may also recruit Treg cells into the tumor microenvironment in favor of tumor growth. Together, our data support that IL-35 could be a valuable biomarker for assessing CRC progression and prognosis in clinical settings.
ISSN:1936-2625