Child Abuse and Epigenetic Mechanisms of Disease Risk

Background Child abuse is highly prevalent and associated with increased risk for a range of health problems, including cancer, cardiovascular disease, diabetes, psychiatric disorders, and other health problems. Little is currently known about the mechanism by which early adversity confers risk for...

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Published in:	American journal of preventive medicine 2013-02, Vol.44 (2), p.101-107
Main Authors:	Yang, Bao-Zhu, PhD, Zhang, Huiping, PhD, Ge, Wenjing, MA, Weder, Natalie, MD, Douglas-Palumberi, Heather, MA, Perepletchikova, Francheska, PhD, Gelernter, Joel, MD, Kaufman, Joan, PhD
Format:	Article
Language:	eng
Subjects:	Adolescent Adversity Analysis. Health state Biological and medical sciences Case-Control Studies Child Child Abuse Child, Preschool Children DNA DNA - analysis DNA Methylation Epidemiology Epigenesis, Genetic Female General aspects Genome-Wide Association Study Health problems Humans Internal Medicine Male Maltreated children Medical sciences Oligonucleotide Array Sequence Analysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Saliva Victimology
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Summary:	Background Child abuse is highly prevalent and associated with increased risk for a range of health problems, including cancer, cardiovascular disease, diabetes, psychiatric disorders, and other health problems. Little is currently known about the mechanism by which early adversity confers risk for health problems later in life. Purpose To determine if there are epigenetic differences associated with child maltreatment that may help explain association between adverse childhood experiences and later health problems. Methods As part of a study examining genetic and environmental factors associated with depression, saliva DNA specimens were collected on 96 maltreated children removed from their parents due to abuse or neglect and 96 demographically matched control children between 2003 and 2010. In 2011, the Illumina 450K BeadChip was used on stored DNA specimens and analyzed to examine whole-genome methylation differences between maltreated and control children. Results After controlling for multiple comparisons, maltreated and control children had significantly different methylation values at 2868 CpG sites ( p
ISSN:	0749-3797 1873-2607