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Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine
It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperh...
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| Published in: | BMC neurology 2013-08, Vol.13 (1), p.103-103 |
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| container_title | BMC neurology |
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| creator | Azimova, Julia E Sergeev, Alexey V Korobeynikova, Liubov A Kondratieva, Natalia S Kokaeva, Zarema G Shaikhaev, Gadji O Skorobogatykh, Kirill V Fokina, Natalia M Tabeeva, Gyusal R Klimov, Eugene A |
| description | It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.
We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.
We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.
Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine. |
| doi_str_mv | 10.1186/1471-2377-13-103 |
| format | article |
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We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.
We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.
Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.</description><identifier>ISSN: 1471-2377</identifier><identifier>EISSN: 1471-2377</identifier><identifier>DOI: 10.1186/1471-2377-13-103</identifier><identifier>PMID: 23915182</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Adolescent ; Adult ; Aged ; Comparative analysis ; Cytosine ; DNA Mutational Analysis ; Electroencephalography ; Evoked Potentials, Visual - physiology ; Gene Frequency ; Genes ; Genetic Predisposition to Disease ; Genetics ; Genotype ; Headaches ; Homocysteine ; Humans ; Hypotheses ; Metabolites ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; Migraine ; Migraine with Aura - genetics ; Migraine with Aura - physiopathology ; Migraine without Aura - genetics ; Migraine without Aura - physiopathology ; Mutation ; Photic Stimulation ; Polymorphism, Genetic - genetics ; Population ; Values ; Young Adult</subject><ispartof>BMC neurology, 2013-08, Vol.13 (1), p.103-103</ispartof><rights>2013 Azimova et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Azimova et al.; licensee BioMed Central Ltd. 2013 Azimova et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750291/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1419963223?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23915182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azimova, Julia E</creatorcontrib><creatorcontrib>Sergeev, Alexey V</creatorcontrib><creatorcontrib>Korobeynikova, Liubov A</creatorcontrib><creatorcontrib>Kondratieva, Natalia S</creatorcontrib><creatorcontrib>Kokaeva, Zarema G</creatorcontrib><creatorcontrib>Shaikhaev, Gadji O</creatorcontrib><creatorcontrib>Skorobogatykh, Kirill V</creatorcontrib><creatorcontrib>Fokina, Natalia M</creatorcontrib><creatorcontrib>Tabeeva, Gyusal R</creatorcontrib><creatorcontrib>Klimov, Eugene A</creatorcontrib><title>Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine</title><title>BMC neurology</title><addtitle>BMC Neurol</addtitle><description>It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.
We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.
We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.
Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Comparative analysis</subject><subject>Cytosine</subject><subject>DNA Mutational Analysis</subject><subject>Electroencephalography</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Headaches</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Metabolites</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>Migraine</subject><subject>Migraine with Aura - genetics</subject><subject>Migraine with Aura - physiopathology</subject><subject>Migraine without Aura - genetics</subject><subject>Migraine without Aura - physiopathology</subject><subject>Mutation</subject><subject>Photic Stimulation</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Population</subject><subject>Values</subject><subject>Young Adult</subject><issn>1471-2377</issn><issn>1471-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkc1rFTEUxYMotn26dyUBN25Gc3PnKxtBHq0VKoLUdUgyyUzKTDIm84T33zvv9YNWEFwl5Jzzy-VcQt4A-wDQ1h-hbKDg2DQFYAEMn5HTh6fnj-4n5CznG8agaUt4SU44Cqig5aekP3fOmiXT6Oi368uLH7S3wdI5jvsppnnweaIx0GWw1Iw-eKNGqkJH7bimUpyHffZxjP1RMINKyiw2-bx4c2ROvk_KB_uKvHBqzPb13bkhPy_Or7eXxdX3L1-3n68KjW2zFK4sa-5qFE4AiMpWGhoOQqNjQnTImG4tdq1qG6t1p1kLjXBViV1pkbPa4YZ8uuXOOz3ZztiwJDXKOflJpb2MysunSvCD7ONviU3FuIAVsL0FaB__AXiqmDjJQ9HyULQElOseVsr7uzFS_LWzeZGTz8aOowo27vIawJIhq5H_hxUElrxaIxvy7i_rTdylsPZ5dIkVxw9_v31cwcPo90vHPzP9r1A</recordid><startdate>20130805</startdate><enddate>20130805</enddate><creator>Azimova, Julia E</creator><creator>Sergeev, Alexey V</creator><creator>Korobeynikova, Liubov A</creator><creator>Kondratieva, Natalia S</creator><creator>Kokaeva, Zarema G</creator><creator>Shaikhaev, Gadji O</creator><creator>Skorobogatykh, Kirill V</creator><creator>Fokina, Natalia M</creator><creator>Tabeeva, Gyusal R</creator><creator>Klimov, Eugene A</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130805</creationdate><title>Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine</title><author>Azimova, Julia E ; Sergeev, Alexey V ; Korobeynikova, Liubov A ; Kondratieva, Natalia S ; Kokaeva, Zarema G ; Shaikhaev, Gadji O ; Skorobogatykh, Kirill V ; Fokina, Natalia M ; Tabeeva, Gyusal R ; Klimov, Eugene A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b387t-f4462f639f91195e5b17219b3f099d300b8e3d8a87ebbdb08179f543d4e3206f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Comparative analysis</topic><topic>Cytosine</topic><topic>DNA Mutational Analysis</topic><topic>Electroencephalography</topic><topic>Evoked Potentials, Visual - physiology</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Headaches</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Metabolites</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>Migraine</topic><topic>Migraine with Aura - genetics</topic><topic>Migraine with Aura - physiopathology</topic><topic>Migraine without Aura - genetics</topic><topic>Migraine without Aura - physiopathology</topic><topic>Mutation</topic><topic>Photic Stimulation</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Population</topic><topic>Values</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azimova, Julia E</creatorcontrib><creatorcontrib>Sergeev, Alexey V</creatorcontrib><creatorcontrib>Korobeynikova, Liubov A</creatorcontrib><creatorcontrib>Kondratieva, Natalia S</creatorcontrib><creatorcontrib>Kokaeva, Zarema G</creatorcontrib><creatorcontrib>Shaikhaev, Gadji O</creatorcontrib><creatorcontrib>Skorobogatykh, Kirill V</creatorcontrib><creatorcontrib>Fokina, Natalia M</creatorcontrib><creatorcontrib>Tabeeva, Gyusal R</creatorcontrib><creatorcontrib>Klimov, Eugene A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azimova, Julia E</au><au>Sergeev, Alexey V</au><au>Korobeynikova, Liubov A</au><au>Kondratieva, Natalia S</au><au>Kokaeva, Zarema G</au><au>Shaikhaev, Gadji O</au><au>Skorobogatykh, Kirill V</au><au>Fokina, Natalia M</au><au>Tabeeva, Gyusal R</au><au>Klimov, Eugene A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine</atitle><jtitle>BMC neurology</jtitle><addtitle>BMC Neurol</addtitle><date>2013-08-05</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>103</spage><epage>103</epage><pages>103-103</pages><issn>1471-2377</issn><eissn>1471-2377</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Article-2</notes><notes>ObjectType-Feature-1</notes><abstract>It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease.
We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR.
We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients.
Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>23915182</pmid><doi>10.1186/1471-2377-13-103</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC neurology, 2013-08, Vol.13 (1), p.103-103 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Adolescent Adult Aged Comparative analysis Cytosine DNA Mutational Analysis Electroencephalography Evoked Potentials, Visual - physiology Gene Frequency Genes Genetic Predisposition to Disease Genetics Genotype Headaches Homocysteine Humans Hypotheses Metabolites Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Migraine Migraine with Aura - genetics Migraine with Aura - physiopathology Migraine without Aura - genetics Migraine without Aura - physiopathology Mutation Photic Stimulation Polymorphism, Genetic - genetics Population Values Young Adult |
| title | Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine |
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