Effects of MTHFR gene polymorphism on the clinical and electrophysiological characteristics of migraine

It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperh...

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Bibliographic Details
Published in:BMC neurology 2013-08, Vol.13 (1), p.103-103
Main Authors: Azimova, Julia E, Sergeev, Alexey V, Korobeynikova, Liubov A, Kondratieva, Natalia S, Kokaeva, Zarema G, Shaikhaev, Gadji O, Skorobogatykh, Kirill V, Fokina, Natalia M, Tabeeva, Gyusal R, Klimov, Eugene A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Comparative analysis
Cytosine
DNA Mutational Analysis
Electroencephalography
Evoked Potentials, Visual - physiology
Gene Frequency
Genes
Genetic Predisposition to Disease
Genetics
Genotype
Headaches
Homocysteine
Humans
Hypotheses
Metabolites
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Migraine
Migraine with Aura - genetics
Migraine with Aura - physiopathology
Migraine without Aura - genetics
Migraine without Aura - physiopathology
Mutation
Photic Stimulation
Polymorphism, Genetic - genetics
Population
Values
Young Adult
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Summary:It was previously shown that the MTHFR gene polymorphism correlated with an increased risk of migraine, particularly migraine with aura. The substitution of cytosine for thymine at the position 677 of the MTHFR gene leads to formation of the thermolabile form of the protein and development of hyperhomocysteinemia, which increases the probability of migraine. The purpose of this study was to determine whether the replacement of C677T in the gene MTHFR influenced any particular symptoms of the disease. We have analyzed clinical and electrophysiological characteristics of 83 patients with migraine (migraine with aura (MA), 19 patients, and migraine without aura (MO), 64 patients, according to the ICHD-II (2003)) taking into account their genotypes of C677T variant of MTHFR. We have shown that MA was significantly more prevalent among the T-allele carriers (37.2%), as compared to the СС genotype patients (0%), р < 0.0001. Patients with TT genotype were not only more likely to have accompanying symptoms (significant differences were found only for photophobia), but also more sensitive to migraine attack triggers. In RP-VEP test results we observed a trend that the T-allele carriers were presented with the decreased N75/P100 amplitudes and a positive habituation index, as compared to the СС genotype patients. Thus, according to our data, the MTHFR genotypes are associated with several clinical and electrophysiological characteristics of migraine.
ISSN:1471-2377
1471-2377
DOI:10.1186/1471-2377-13-103