The type 1 pili regulator gene fimX and pathogenicity island PAI-X as molecular markers of uropathogenic Escherichia coli

Uropathogenic Escherichia coli (UPEC) fall within a larger group of isolates producing extraintestinal disease. UPEC express type 1 pili as a critical virulence determinant mediating adherence to and invasion into urinary tract tissues. Type 1 pili expression is under regulation by a family of site-...

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Published in:Microbiology (Society for General Microbiology) 2013-08, Vol.159 (Pt 8), p.1606-1617
Main Authors: Bateman, Stacey L, Stapleton, Ann E, Stamm, Walter E, Hooton, Thomas M, Seed, Patrick C
Format: Article
Language:English
Subjects:
Biomarkers
Environmental and Evolutionary Microbiology
Escherichia coli Proteins - genetics
Fimbriae, Bacterial - genetics
Genomic Islands
Polymerase Chain Reaction
Recombinases - genetics
Uropathogenic Escherichia coli - genetics
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Summary:Uropathogenic Escherichia coli (UPEC) fall within a larger group of isolates producing extraintestinal disease. UPEC express type 1 pili as a critical virulence determinant mediating adherence to and invasion into urinary tract tissues. Type 1 pili expression is under regulation by a family of site-specific recombinases, including FimX, which is encoded from a genomic island called PAI-X for pathogenicity island of FimX. Using a new multiplex PCR, fimX and the additional PAI-X genes were found to be highly associated with UPEC (144/173 = 83.2 %), and more prevalent in UPEC of lower urinary tract origin (105/120 = 87.5 %) than upper urinary tract origin (39/53 = 74 %; P
ISSN:1350-0872
1465-2080
DOI:10.1099/mic.0.066472-0