Loading…
Tango7 directs cellular remodeling by the Drosophila apoptosome
It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collab...
Saved in:
Published in: | Genes & development 2013-08, Vol.27 (15), p.1650-1655 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3 |
---|---|
cites | cdi_FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3 |
container_end_page | 1655 |
container_issue | 15 |
container_start_page | 1650 |
container_title | Genes & development |
container_volume | 27 |
creator | D'Brot, Alejandro Chen, Po Vaishnav, Mahesh Yuan, Shujun Akey, Christopher W Abrams, John M |
description | It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling. |
doi_str_mv | 10.1101/gad.219287.113 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3744723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1434035112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3</originalsourceid><addsrcrecordid>eNqNUT1PwzAQtRCIlsLKiDKypNixE9sLCJVPqRJLmS3HuaZBSRzsBKn_HkctFWwsd3q6d0_37iF0SfCcEExuSl3MEyITwQOmR2hKUibjlHF-jKZYSBxLmskJOvP-A2Oc4Sw7RZOESkJlgqfobqXb0vKoqByY3kcG6nqotYscNLaAumrLKN9G_QaiB2e97TZVrSPd2a4PqIFzdLLWtYeLfZ-h96fH1eIlXr49vy7ul7FhQvax4YaDXHNIADhNcyCSGClwqHmWrw0YaYAKJqWgJMsEFFQXeaKxYQGznM7Q7U63G_IGCgNt73StOlc12m2V1ZX6O2mrjSrtl6KcMZ7QIHC9F3D2cwDfq6byo1vdgh28IowyTFNCkn9QiSBMUD6qzndUE57jHawPFxGsxoBUCEjtAgp4XLj67eNA_0mEfgPcGY0O</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1418148373</pqid></control><display><type>article</type><title>Tango7 directs cellular remodeling by the Drosophila apoptosome</title><source>Freely Accessible Science Journals</source><source>PubMed Central</source><creator>D'Brot, Alejandro ; Chen, Po ; Vaishnav, Mahesh ; Yuan, Shujun ; Akey, Christopher W ; Abrams, John M</creator><creatorcontrib>D'Brot, Alejandro ; Chen, Po ; Vaishnav, Mahesh ; Yuan, Shujun ; Akey, Christopher W ; Abrams, John M</creatorcontrib><description>It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.</description><identifier>ISSN: 0890-9369</identifier><identifier>EISSN: 1549-5477</identifier><identifier>DOI: 10.1101/gad.219287.113</identifier><identifier>PMID: 23913920</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Apoptosomes - metabolism ; Aryl Hydrocarbon Receptor Nuclear Translocator - genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism ; Caspases - metabolism ; Drosophila ; Drosophila melanogaster - cytology ; Drosophila melanogaster - enzymology ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Fertility - genetics ; Genetic Variation ; Male ; Mutation ; Research Communication ; Spermatogenesis - genetics ; Spermatozoa - enzymology ; Spermatozoa - metabolism</subject><ispartof>Genes & development, 2013-08, Vol.27 (15), p.1650-1655</ispartof><rights>Copyright © 2013 by Cold Spring Harbor Laboratory Press 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3</citedby><cites>FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744723/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744723/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23913920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'Brot, Alejandro</creatorcontrib><creatorcontrib>Chen, Po</creatorcontrib><creatorcontrib>Vaishnav, Mahesh</creatorcontrib><creatorcontrib>Yuan, Shujun</creatorcontrib><creatorcontrib>Akey, Christopher W</creatorcontrib><creatorcontrib>Abrams, John M</creatorcontrib><title>Tango7 directs cellular remodeling by the Drosophila apoptosome</title><title>Genes & development</title><addtitle>Genes Dev</addtitle><description>It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.</description><subject>Animals</subject><subject>Apoptosomes - metabolism</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator - genetics</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism</subject><subject>Caspases - metabolism</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - enzymology</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Fertility - genetics</subject><subject>Genetic Variation</subject><subject>Male</subject><subject>Mutation</subject><subject>Research Communication</subject><subject>Spermatogenesis - genetics</subject><subject>Spermatozoa - enzymology</subject><subject>Spermatozoa - metabolism</subject><issn>0890-9369</issn><issn>1549-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNUT1PwzAQtRCIlsLKiDKypNixE9sLCJVPqRJLmS3HuaZBSRzsBKn_HkctFWwsd3q6d0_37iF0SfCcEExuSl3MEyITwQOmR2hKUibjlHF-jKZYSBxLmskJOvP-A2Oc4Sw7RZOESkJlgqfobqXb0vKoqByY3kcG6nqotYscNLaAumrLKN9G_QaiB2e97TZVrSPd2a4PqIFzdLLWtYeLfZ-h96fH1eIlXr49vy7ul7FhQvax4YaDXHNIADhNcyCSGClwqHmWrw0YaYAKJqWgJMsEFFQXeaKxYQGznM7Q7U63G_IGCgNt73StOlc12m2V1ZX6O2mrjSrtl6KcMZ7QIHC9F3D2cwDfq6byo1vdgh28IowyTFNCkn9QiSBMUD6qzndUE57jHawPFxGsxoBUCEjtAgp4XLj67eNA_0mEfgPcGY0O</recordid><startdate>20130801</startdate><enddate>20130801</enddate><creator>D'Brot, Alejandro</creator><creator>Chen, Po</creator><creator>Vaishnav, Mahesh</creator><creator>Yuan, Shujun</creator><creator>Akey, Christopher W</creator><creator>Abrams, John M</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130801</creationdate><title>Tango7 directs cellular remodeling by the Drosophila apoptosome</title><author>D'Brot, Alejandro ; Chen, Po ; Vaishnav, Mahesh ; Yuan, Shujun ; Akey, Christopher W ; Abrams, John M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Apoptosomes - metabolism</topic><topic>Aryl Hydrocarbon Receptor Nuclear Translocator - genetics</topic><topic>Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism</topic><topic>Caspases - metabolism</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - enzymology</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Fertility - genetics</topic><topic>Genetic Variation</topic><topic>Male</topic><topic>Mutation</topic><topic>Research Communication</topic><topic>Spermatogenesis - genetics</topic><topic>Spermatozoa - enzymology</topic><topic>Spermatozoa - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'Brot, Alejandro</creatorcontrib><creatorcontrib>Chen, Po</creatorcontrib><creatorcontrib>Vaishnav, Mahesh</creatorcontrib><creatorcontrib>Yuan, Shujun</creatorcontrib><creatorcontrib>Akey, Christopher W</creatorcontrib><creatorcontrib>Abrams, John M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'Brot, Alejandro</au><au>Chen, Po</au><au>Vaishnav, Mahesh</au><au>Yuan, Shujun</au><au>Akey, Christopher W</au><au>Abrams, John M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tango7 directs cellular remodeling by the Drosophila apoptosome</atitle><jtitle>Genes & development</jtitle><addtitle>Genes Dev</addtitle><date>2013-08-01</date><risdate>2013</risdate><volume>27</volume><issue>15</issue><spage>1650</spage><epage>1655</epage><pages>1650-1655</pages><issn>0890-9369</issn><eissn>1549-5477</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.</abstract><cop>United States</cop><pub>Cold Spring Harbor Laboratory Press</pub><pmid>23913920</pmid><doi>10.1101/gad.219287.113</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0890-9369 |
ispartof | Genes & development, 2013-08, Vol.27 (15), p.1650-1655 |
issn | 0890-9369 1549-5477 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3744723 |
source | Freely Accessible Science Journals; PubMed Central |
subjects | Animals Apoptosomes - metabolism Aryl Hydrocarbon Receptor Nuclear Translocator - genetics Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism Caspases - metabolism Drosophila Drosophila melanogaster - cytology Drosophila melanogaster - enzymology Drosophila Proteins - genetics Drosophila Proteins - metabolism Fertility - genetics Genetic Variation Male Mutation Research Communication Spermatogenesis - genetics Spermatozoa - enzymology Spermatozoa - metabolism |
title | Tango7 directs cellular remodeling by the Drosophila apoptosome |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T20%3A35%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tango7%20directs%20cellular%20remodeling%20by%20the%20Drosophila%20apoptosome&rft.jtitle=Genes%20&%20development&rft.au=D'Brot,%20Alejandro&rft.date=2013-08-01&rft.volume=27&rft.issue=15&rft.spage=1650&rft.epage=1655&rft.pages=1650-1655&rft.issn=0890-9369&rft.eissn=1549-5477&rft_id=info:doi/10.1101/gad.219287.113&rft_dat=%3Cproquest_pubme%3E1434035112%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c489t-c7c7e9f7e2ee735be191c98091cb6bfcec9ce38499831668ed3adb2a0c43164b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1418148373&rft_id=info:pmid/23913920&rfr_iscdi=true |