Tango7 directs cellular remodeling by the Drosophila apoptosome

It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collab...

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Bibliographic Details
Published in:Genes & development 2013-08, Vol.27 (15), p.1650-1655
Main Authors: D'Brot, Alejandro, Chen, Po, Vaishnav, Mahesh, Yuan, Shujun, Akey, Christopher W, Abrams, John M
Format: Article
Language:English
Subjects:
Animals
Apoptosomes - metabolism
Aryl Hydrocarbon Receptor Nuclear Translocator - genetics
Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism
Caspases - metabolism
Drosophila
Drosophila melanogaster - cytology
Drosophila melanogaster - enzymology
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Fertility - genetics
Genetic Variation
Male
Mutation
Research Communication
Spermatogenesis - genetics
Spermatozoa - enzymology
Spermatozoa - metabolism
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Summary:It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Drosophila apoptosome to drive a caspase-dependent remodeling process needed to resolve individual sperm from a syncytium. In these cells, Tango7 is required for caspase activity and localizes to the active apoptosome compartment via its C terminus. Furthermore, Tango7 directly stimulates the activity of this complex in vitro. We propose that Tango7 specifies the Drosophila apoptosome as an effector of cellular remodeling.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.219287.113