Genetic associations of psoriasis in a Pakistani population

Summary Background Genetic predisposition to psoriasis, an inflammatory skin disease affecting 0·2–4% of the world population, is well established. Thus far, 41 psoriasis susceptibility loci reach genome‐wide significance (P ≤ 5 × 10−8). Identification of genetic susceptibility loci in diverse popul...

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Published in:British journal of dermatology (1951) 2013-08, Vol.169 (2), p.406-411
Main Authors: Shaiq, P.A., Stuart, P.E., Latif, A., Schmotzer, C., Kazmi, A.H., Khan, M.S., Azam, M., Tejasvi, T., Voorhees, J.J., Raja, G.K., Elder, J.T., Qamar, R., Nair, R.P.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adult
Age of Onset
Autoimmune diseases
Biological and medical sciences
Dermatology
Female
Genetic Loci - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Genotype
Haplotypes
HLA-C Antigens - genetics
Humans
Interleukin-13 - genetics
Male
Medical sciences
Nitric Oxide Synthase Type II - genetics
Pakistan - ethnology
Polymorphism, Single Nucleotide
Psoriasis - genetics
Psoriasis. Parapsoriasis. Lichen
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics
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Summary:Summary Background Genetic predisposition to psoriasis, an inflammatory skin disease affecting 0·2–4% of the world population, is well established. Thus far, 41 psoriasis susceptibility loci reach genome‐wide significance (P ≤ 5 × 10−8). Identification of genetic susceptibility loci in diverse populations will help understand the underlying biology of psoriasis susceptibility. Objectives The primary objective of this study was to examine psoriasis susceptibility associations previously reported in Chinese and caucasian populations in a Pakistani cohort. Methods Blood samples and phenotype data were collected from psoriasis cases and controls in Islamabad, Pakistan. DNA was isolated and genotypes of selected susceptibility markers were determined. The data were analysed using χ2 tests or logistic regression for psoriasis association. Results HLA‐Cw6 showed the strongest association [odds ratio (OR) 2·43, P = 2·3 × 10−12]. HLA‐Cw1 showed marginally significant association (OR 1·66, P = 0·049), suggesting that the HLA‐Cw1‐B46 risk haplotype may be present in the Pakistani population. Three other loci (IL4/IL13, NOS2, TRAF3IP2) showed nominally significant association (P 
ISSN:0007-0963
1365-2133
DOI:10.1111/bjd.12313