Severe growth hormone deficiency is rare in surgically-cured acromegalics

Growth hormone deficiency (GHD) in surgically-cured acromegalics has been reported to negatively affect their metabolic condition and quality of life (QOL). The incidence of GHD, its causes, and its effects on their physio-psychological condition remain to be examined in detail. We performed a retro...

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Bibliographic Details
Published in:Pituitary 2013-09, Vol.16 (3), p.326-332
Main Authors: Fujio, Shingo, Tokimura, Hiroshi, Hirano, Hirofumi, Hanaya, Ryosuke, Kubo, Fumikatsu, Yunoue, Shunji, Bohara, Manoj, Kinoshita, Yasuyuki, Tominaga, Atsushi, Arimura, Hiroshi, Arita, Kazunori
Format: Article
Language:English
Subjects:
Acromegaly - blood
Acromegaly - surgery
Adolescent
Adult
Aged
Body Mass Index
Endocrinology
Female
Growth Hormone - blood
Growth Hormone - deficiency
Human Physiology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Postoperative Period
Quality of Life
Young Adult
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Summary:Growth hormone deficiency (GHD) in surgically-cured acromegalics has been reported to negatively affect their metabolic condition and quality of life (QOL). The incidence of GHD, its causes, and its effects on their physio-psychological condition remain to be examined in detail. We performed a retrospective study to investigate GH secretory function in surgically-cured acromegalics, prognostic factors of GHD, and its impact on QOL. The study population consisted of 72 acromegalics who were determined to be surgically cured according to the Cortina consensus criteria. We recorded the incidence of impaired GH secretory function based on the peak GH level during postoperative insulin tolerance test (ITT) which lowered their nadir blood sugar to under 50 mg/dL. Their QOL was evaluated by SF-36. In surgically-cured acromegalics, the incidence of severe GHD (peak GH during ITT ≦ 3.0 μg/L) was 12.5 % (9/72). The preoperative tumor size was significantly larger in patients with severe GHD than without severe GHD (21.9 ± 9.0 vs. 15.5 ± 7.1 mm, p  = 0.017). The peak GH levels during postoperative ITT were statistically correlated with the physical but not the mental component summary of the SF-36 score. The incidence of GHD was 12.5 % in our surgically-cured acromegalics. As some QOL aspects are positively related with peak GH levels during postoperative ITT, efforts should be made to preserve pituitary function in acromegalic patients undergoing adenomectomy.
ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-012-0424-6