Gene expression differences during the heterogeneous progression of peripheral atherosclerosis in familial hypercholesterolemic swine

The heterogeneous progression of atherosclerotic disease in the peripheral arteries is currently not well understood. In humans, artery specific disease progression is partly attributed to the local hemodynamic environments. However, despite similar hemodynamic environments, porcine brachial arterie...

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Bibliographic Details
Published in:BMC genomics 2013-07, Vol.14 (1), p.443-443
Main Authors: Bahls, Martin, Bidwell, Christopher A, Hu, Juan, Tellez, Armando, Kaluza, Greg L, Granada, Juan F, Krueger, Christian G, Reed, Jess D, Laughlin, M Harold, Van Alstine, William G, Newcomer, Sean C
Format: Article
Language:English
Subjects:
Animal sciences
Animals
Atherosclerosis
Atherosclerosis - complications
Atherosclerosis - genetics
Atherosclerosis - pathology
Blood pressure
Complications and side effects
Disease Progression
Epidemiology
Experiments
Gene expression
Genetic research
Heart attacks
Hypercholesterolemia
Hyperlipoproteinemia Type II - complications
Microbiology
Peripheral Arterial Disease - complications
Peripheral Arterial Disease - genetics
Peripheral Arterial Disease - pathology
Physiological aspects
Plasmids
Proteins
Risk factors
Studies
Swine
Transcriptome
Veins & arteries
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Summary:The heterogeneous progression of atherosclerotic disease in the peripheral arteries is currently not well understood. In humans, artery specific disease progression is partly attributed to the local hemodynamic environments. However, despite similar hemodynamic environments, porcine brachial arteries are protected while femoral arteries are highly susceptible to advanced lesion formation. The aim of this investigation was to determine whether artery specific gene expression patterns contribute to the uneven distribution of peripheral arterial disease (PAD) in Rapacz Familial-Hypercholesterolemic (FHC) swine. Histological results confirmed rapid atherosclerotic disease progression in femoral but not brachial arteries. A total of 18,922 probe sets had sufficient signal abundance. A main effect for age and artery was observed for 1784 and 1256 probe sets, respectively. A significant age x artery interaction was found for 184 probe sets. Furthermore, comparison between arteries found a decrease from 714 to 370 differentially expressed transcripts from nine months to two years of age. Gene ontology analysis of the 56 genes with a main effect for artery and an age x artery interaction identified vascular smooth muscle contraction as enhanced biological signaling pathway. This is the first investigation to report that the total number of differential genes decreases with diverging atherosclerotic disease pattern between porcine brachial and femoral arteries.
ISSN:1471-2164
1471-2164
DOI:10.1186/1471-2164-14-443