Lactate and glucose exchange across the forearm, legs, and splanchnic bed during and after prolonged leg exercise

The net exchange of glucose and lactate across the leg and the splanchnic bed and the arterialdeep venous (A-DV) differences for these substrates in the forearm were determined in healthy subjects during 3-3.5 h of leg exercise (bicycle ergometer) at 58% maximum O(2) uptake and during a 40-min post-...

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Bibliographic Details
Published in:The Journal of clinical investigation 1982-01, Vol.69 (1), p.45-54
Main Authors: Ahlborg, G, Felig, P
Format: Article
Language:English
Subjects:
Adult
Forearm
Glucose - metabolism
Heart Rate
Humans
Lactates - metabolism
Lactic Acid
Leg - blood supply
Male
Muscles - metabolism
Oxygen Consumption
Physical Exertion
Regional Blood Flow
Respiration
Space life sciences
Time Factors
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Summary:The net exchange of glucose and lactate across the leg and the splanchnic bed and the arterialdeep venous (A-DV) differences for these substrates in the forearm were determined in healthy subjects during 3-3.5 h of leg exercise (bicycle ergometer) at 58% maximum O(2) uptake and during a 40-min post-exercise recovery period. Leg glucose uptake rose 16-fold during exercise and throughout the exercise period exceeded splanchnic glucose output. The latter reached a peak increment (3.5 times basal) at 90 min and fell by 60% during the third hour. As a result, blood glucose declined 40%, reaching frank hypoglycemia (blood glucose,
ISSN:0021-9738
1558-8238
DOI:10.1172/jci110440