Association of arterial stiffness with single nucleotide polymorphism rs1333049 and metabolic risk factors

Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with...

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Bibliographic Details
Published in:Cardiovascular diabetology 2013-06, Vol.12 (1), p.93-93, Article 93
Main Authors: Phababpha, Suphawadee, Kukongviriyapan, Upa, Pakdeechote, Poungrat, Senggunprai, Laddawan, Kukongviriyapan, Veerapol, Settasatian, Chatri, Tatsanavivat, Pyatat, Intharaphet, Phongsak, Senthong, Vichai, Komanasin, Nantarat, Settasatian, Nongnuch, Greenwald, Stephen E
Format: Article
Language:English
Subjects:
Adult
Aged
Ankle
Asian Continental Ancestry Group - genetics
Blood pressure
Body mass index
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - genetics
Cell cycle
Cholesterol
Chromosomes
Chromosomes, Human, Pair 9 - genetics
Cyclin-dependent kinases
Diabetes
Education
Female
Genetic Predisposition to Disease
Glucose
Homeostasis
Humans
Insulin
Insulin resistance
Kinases
Lipoproteins
Male
Medicine
Mens health
Metabolic Syndrome - ethnology
Metabolic Syndrome - genetics
Middle Aged
Mortality
Original Investigation
Polymorphism, Single Nucleotide
Population
Risk factors
Thailand
Vascular Stiffness - genetics
Veins & arteries
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Summary:Increased arterial stiffness is a cardiovascular outcome of metabolic syndrome (MetS). The chromosome 9p21 locus has been identified as a major locus for risk of coronary artery disease (CAD). The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction. Increased arterial stiffness could be the link between the 9p21 polymorphism and increased cardiovascular risk. Since the impact of a genetic polymorphism on arterial stiffness especially in Asian populations has not been well defined, we aimed to investigate the association of arterial stiffness with rs 1333049 variant on chromosome 9p21.3 in Thai subjects with and without MetS risk factors. A total of 208 Thai subjects, aged 35-75 years, 135 with and 73 without MetS, according to IDF and NCEP-ATPIII criteria, were included in this study. Aortic-femoral pulse wave velocity (afPWV), brachial-ankle pulse wave velocity (baPWV) and aortic ankle pulse wave velocity (aaPWV) were measured and used as markers of arterial stiffness. The chromosome 9p21.3 locus, represented by the rs 1333049 variant and blood biochemistry were evaluated. Arterial stiffness was elevated in subjects with MetS when compared with nonMetS subjects. PWV, especially afPWV increased progressively with increasing number of MetS risk factors (r = 0.322, P
ISSN:1475-2840
1475-2840
DOI:10.1186/1475-2840-12-93