Socioeconomic status as a risk factor for dementia death: individual participant meta-analysis of 86 508 men and women from the UK

Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base. To examine the association between socioeconomic status in early life and adulthood with l...

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Bibliographic Details
Published in:British journal of psychiatry 2013-07, Vol.203 (1), p.10-17
Main Authors: Russ, Tom C., Stamatakis, Emmanuel, Hamer, Mark, Starr, John M., Kivimäki, Mika, Batty, G. David
Format: Article
Language:English
Subjects:
Age
Cohort analysis
Comorbidity
Death
Death & dying
Dementia
Dementia - mortality
Dementia disorders
Educational attainment
Educational Status
Etiology
Female
Health Behavior
Health Surveys
Humans
Life events
Male
Men
Meta-analysis
Mortality
Prognosis
Psychiatry
Review
Review Article
Risk behavior
Risk Factors
Risk-Taking
Smoking
Social Class
Social classes
Socioeconomic Factors
Socioeconomic status
Systematic review
United Kingdom - epidemiology
Women
Womens health
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Summary:Life-course socioeconomic factors may have a role in dementia aetiology but there is a current paucity of studies. Meta-analyses of individual participant data would considerably strengthen this evidence base. To examine the association between socioeconomic status in early life and adulthood with later dementia death. Individual participant meta-analysis of 11 prospective cohort studies (1994-2004, n = 86 508). Leaving full-time education at an earlier age was associated with an increased risk of dementia death in women (fully adjusted hazard ratio (HR) for age ≤14 v. age ≥16: HR = 1.76, 95% CI 1.23-2.53) but not men. Occupational social class was not statistically significantly associated with dementia death in men or women. Lower educational attainment in women was associated with an increased risk of dementia-related death independently of common risk behaviours and comorbidities.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.112.119479