GABAA Receptors Predict Aversion-Related Brain Responses: An fMRI-PET Investigation in Healthy Humans

The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cue...

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Published in:Neuropsychopharmacology (New York, N.Y.) N.Y.), 2013-07, Vol.38 (8), p.1438-1450
Main Authors: HAYES, Dave J, DUNCAN, Niall W, SCHIRRMACHER, Ralf, READER, Andrew J, DOYON, Julien, RAINVILLE, Pierre, NORTHOFF, Georg, WIEBKING, Christine, PIETRUSKA, Karin, PENGMIN QIN, LANG, Stefan, GAGNON, Jean, GRAVEL BLNG, Paul, VERHAEGHE, Jeroen, KOSTIKOV, Alexey P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Avoidance Learning - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain - diagnostic imaging
Brain - metabolism
Brain research
Emotions
Female
Forecasting
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging - methods
Male
Medical imaging
Medical research
Mental health
Neuroimaging
Neurotransmission and behavior
Original
Photic Stimulation - methods
Positron-Emission Tomography - methods
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Receptors, GABA-A - metabolism
Young Adult
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Summary:The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversive-aversive interaction were predicted by GABAA receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.
ISSN:0893-133X
1740-634X
DOI:10.1038/npp.2013.40