Calcium Absorption Response to Cholecalciferol Supplementation in Hemodialysis

Recent understanding of extrarenal production of calcitriol has led to the use of more vitamin D supplementation in CKD populations. This paper reports the effect of cholecalciferol supplementation on calcium absorption. Paired calcium absorption tests were done before and after 12-13 weeks of 20,00...

Full description

Saved in:
Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2013-06, Vol.8 (6), p.1003-1008
Main Authors: Armas, Laura A G, Zena, Mohsen, Lund, Richard, Heaney, Robert P
Format: Article
Language:English
Subjects:
Aged
Calcium Carbonate - administration & dosage
Calcium Carbonate - blood
Calcium, Dietary - blood
Cholecalciferol - blood
Cholecalciferol - therapeutic use
Dietary Supplements
Female
Humans
Intestinal Absorption - drug effects
Male
Middle Aged
Nebraska
Original
Renal Dialysis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - therapy
Time Factors
Treatment Outcome
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamins - blood
Vitamins - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent understanding of extrarenal production of calcitriol has led to the use of more vitamin D supplementation in CKD populations. This paper reports the effect of cholecalciferol supplementation on calcium absorption. Paired calcium absorption tests were done before and after 12-13 weeks of 20,000 IU weekly cholecalciferol supplementation in 30 participants with stage 5 CKD on hemodialysis. The study was conducted from April to December of 2011. Calcium absorption was tested with a standardized meal containing 300 mg calcium carbonate intrinsically labeled with (45)Ca; 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured. 25-Hydroxyvitamin D rose from 14.2 ng/ml (11.5-18.5) at baseline to 49.3 ng/ml (42.3-58.1) at the end of the study (P
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.08610812