Prospective Cohort Study of Microbial and Inflammatory Events Immediately Preceding Escherichia coli Recurrent Urinary Tract Infection in Women

BackgroundA prospective cohort study was conducted to characterize the temporal sequence of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection (rUTI) MethodsWomen with acute cystitis and a history of UTI within the previous year self-collected...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2009-08, Vol.200 (4), p.528-536
Main Authors: Czaja, C. A., Stamm, W. E., Stapleton, A. E., Roberts, P. L., Hawn, T. R., Scholes, D., Samadpour, M., Hultgren, S. J., Hooton, T. M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bacteria
Bacteriuria
Biological and medical sciences
Cohort Studies
Cytokines
Escherichia coli
Escherichia coli Infections - microbiology
Female
Fundamental and applied biological sciences. Psychology
Humans
Infections
Infectious diseases
Inflammation - complications
Medical sciences
Microbiology
Middle Aged
Recurrence
Risk Factors
Sexual intercourse
Specimen Handling
Specimens
Symptoms
Urinary bladder
Urinary tract infections
Urinary Tract Infections - microbiology
Urine
Young Adult
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundA prospective cohort study was conducted to characterize the temporal sequence of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection (rUTI) MethodsWomen with acute cystitis and a history of UTI within the previous year self-collected periurethral and urine samples daily and recorded measurements of urine leukocyte esterase, symptoms, and sexual intercourse daily for 3 months. rUTI strains were characterized by pulsed-field gel electrophoresis and genomic virulence profiling. Urinary cytokine levels were measured ResultsThere were 38 E. coli rUTIs in 29 of 104 women. The prevalence of periurethral rUTI strain carriage increased from 46% to 90% during the 14 days immediately preceding rUTI, with similar increases in same-strain bacteriuria (from 7% to 69%), leukocyte esterase (from 31% to 64%), and symptoms (from 3% to 43%), most notably 2–3 days before rUTI (P
ISSN:0022-1899
1537-6613
DOI:10.1086/600385