Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients

As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smo...

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Bibliographic Details
Published in:Clinics (São Paulo, Brazil) Brazil), 2013-06, Vol.68 (6), p.738-744
Main Authors: Moyses, Raquel Ajub, López, Rossana Verónica Mendoza, Cury, Patrícia Maluf, Siqueira, Sheila Aparecida Coelho, Curioni, Otávio Alberto, de Gois Filho, José Francisco, Figueiredo, David Livingstone Alves, Tajara, Eloiza Helena, Michaluart, Pedro
Format: Article
Language:English
Subjects:
Age
Age Distribution
Aged
Alcohol
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Brazil
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Clinical Science
Cross-Sectional Studies
Female
Head and Neck Neoplasms
Head and Neck Neoplasms - epidemiology
Head and Neck Neoplasms - pathology
Humans
Life Style
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Risk Factors
Sex Distribution
Smoking - adverse effects
Smoking - epidemiology
Socioeconomic Factors
Tobacco
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Summary:As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project – Gencapo. The patients who smoked and drank were younger, and those who smoked were leaner than the other patients, regardless of alcohol consumption. The non-smokers/non-drinkers were typically elderly white females who had more differentiated oral cavity cancers and fewer first-degree relatives who smoked. The patients who drank presented significantly more frequent nodal metastasis, and those who smoked presented less-differentiated tumors. The patients with squamous cell carcinoma of the head and neck demonstrated demographic, clinical, and pathological features that were markedly different according to their smoking and drinking habits. A subset of elderly females who had oral cavity cancer and had never smoked or consumed alcohol was notable. Alcohol consumption seemed to be related to nodal metastasis, whereas smoking correlated with the degree of differentiation.
ISSN:1807-5932
1980-5322
DOI:10.6061/clinics/2013(06)03