Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study

Objective To assess the influence of infertility and fertility drugs on risk of ovarian tumors. Design Case-control study (Mayo Clinic Ovarian Cancer Study). Setting Ongoing academic study of ovarian cancer. Patient(s) A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency mat...

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Bibliographic Details
Published in:Fertility and sterility 2013-06, Vol.99 (7), p.2031-2036
Main Authors: Asante, Albert, M.D., M.P.H, Leonard, Phoebe H., M.D, Weaver, Amy L, Goode, Ellen L., Ph.D., M.P.H, Jensen, Jani R., M.D, Stewart, Elizabeth A., M.D, Coddington, Charles C., M.D
Format: Article
Language:English
Subjects:
Aged
animal ovaries
Borderline tumors
case control
Case-Control Studies
contraception
drugs
Female
Fertility
Fertility Agents, Female - adverse effects
fertility drugs
Gravidity
Humans
Incidence
Infertility, Female - drug therapy
Infertility, Female - physiopathology
Internal Medicine
Logistic Models
Middle Aged
Minnesota - epidemiology
Multivariate Analysis
Obstetrics and Gynecology
Odds Ratio
ovarian neoplasms
Ovarian Neoplasms - chemically induced
Ovarian Neoplasms - epidemiology
ovarian tumors
patients
Pregnancy
Prevalence
primary infertility
prospective studies
questionnaires
Reproductive Techniques, Assisted - adverse effects
risk
Risk Assessment
Risk Factors
Surveys and Questionnaires
women
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Summary:Objective To assess the influence of infertility and fertility drugs on risk of ovarian tumors. Design Case-control study (Mayo Clinic Ovarian Cancer Study). Setting Ongoing academic study of ovarian cancer. Patient(s) A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use. Intervention(s) None. Main Outcome Measure(s) Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders. Result(s) Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors. Conclusion(s) We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2013.02.010