Inherently Multimodal Nanoparticle-Driven Tracking and Real-Time Delineation of Orthotopic Prostate Tumors and Micrometastases

Prostate cancer is the most common cancer among men and the second cause of male cancer-related deaths. There are currently three critical needs in prostate cancer imaging to personalize cancer treatment: (1) accurate intraprostatic imaging for multiple foci and extra-capsular extent; (2) monitoring...

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Bibliographic Details
Published in:ACS nano 2013-05, Vol.7 (5), p.4221-4232
Main Authors: Liu, Tracy W, MacDonald, Thomas D, Jin, Cheng S, Gold, Joseph M, Bristow, Robert G, Wilson, Brian C, Zheng, Gang
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Bones
Cancer
Cell Line, Tumor
Copper Radioisotopes
Delineation
Fluorescence
Humans
Imaging
Lipid Bilayers - chemistry
Male
Mice
Mice, Nude
Monitoring
Multimodal Imaging
Nanoparticles - chemistry
Nanostructure
Neoplasm Micrometastasis - diagnostic imaging
Porphyrins - chemistry
Porphyrins - metabolism
Porphyrins - pharmacokinetics
Positron-Emission Tomography
Prostate
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Time Factors
Tomography, X-Ray Computed
Tumors
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Summary:Prostate cancer is the most common cancer among men and the second cause of male cancer-related deaths. There are currently three critical needs in prostate cancer imaging to personalize cancer treatment: (1) accurate intraprostatic imaging for multiple foci and extra-capsular extent; (2) monitoring local and systemic treatment response and predicting recurrence; and (3) more sensitive imaging of occult prostate cancer bone metastases. Recently, our lab developed porphysomes, inherently multimodal, all-organic nanoparticles with flexible and robust radiochemistry. Herein, we validate the first in vivo application of 64Cu-porphysomes in clinically relevant orthotopic prostate and bony metastatic cancer models. We demonstrate clear multimodal delineation of orthotopic tumors on both the macro- and the microscopic scales (using both PET and fluorescence) and sensitively detected small bony metastases (
ISSN:1936-0851
1936-086X
DOI:10.1021/nn400669r