Intra-oral PTH Administration Promotes Tooth Extraction Socket Healing

Intermittent parathyroid hormone (PTH) administration increases systemic and craniofacial bone mass. However, the effect of PTH therapy on healing of tooth extraction sites is unknown. The aims of this study were to determine the effect of PTH therapy on tooth extraction socket healing and to examin...

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Bibliographic Details
Published in:Journal of dental research 2013-06, Vol.92 (6), p.553-559
Main Authors: Kuroshima, S., Kovacic, B.L., Kozloff, K.M., McCauley, L.K., Yamashita, J.
Format: Article
Language:English
Subjects:
Acid Phosphatase - analysis
Alveolar Process - drug effects
Alveolar Process - pathology
Animals
Biomarkers - analysis
Bone Density - drug effects
Bone healing
Bone mass
Collagen
Collagen - analysis
Computed tomography
Connective Tissue - drug effects
Connective Tissue - pathology
Connective tissues
Dentistry
Injection
Injections
Injections, Subcutaneous
Isoenzymes - analysis
Mandible
Mandible - drug effects
Mandible - pathology
Mandible - surgery
Maxilla - drug effects
Maxilla - pathology
Maxilla - surgery
Menopause
Molar - surgery
Molars
Neutrophils
Neutrophils - pathology
Osteoblasts - pathology
Osteoclasts - pathology
Osteocytes - pathology
Osteogenesis - drug effects
Parathyroid
Parathyroid hormone
Parathyroid Hormone - administration & dosage
Phosphatase
Random Allocation
Rats
Rats, Sprague-Dawley
Research Reports
Tartrate-Resistant Acid Phosphatase
Teeth
Time Factors
Tooth Extraction
Tooth Socket - drug effects
Wound healing
Wound Healing - drug effects
X-Ray Microtomography
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Summary:Intermittent parathyroid hormone (PTH) administration increases systemic and craniofacial bone mass. However, the effect of PTH therapy on healing of tooth extraction sites is unknown. The aims of this study were to determine the effect of PTH therapy on tooth extraction socket healing and to examine whether PTH intra-oral injection promotes healing. The mandibular first molars were extracted in rats, and subcutaneous PTH was administered intermittently for 7, 14, and 28 days. In a second study, maxillary second molars were extracted, and PTH was administered by either subcutaneous or intra-oral injection to determine the efficacy of intra-oral PTH administration. Healing was assessed by micro-computed tomography and histomorphometric analyses. PTH therapy accelerated the entire healing process and promoted both hard- and soft-tissue healing by increasing bone fill and connective tissue maturation. PTH therapy by intra-oral injection was as effective as subcutaneous injection in promoting tooth extraction socket healing. The findings suggest that PTH therapy promotes tooth extraction socket healing and that intra-oral injections can be used to administer PTH.
ISSN:0022-0345
1544-0591
1544-0591
DOI:10.1177/0022034513487558