Olfactomedin-like 3 (OLFML3) gene expression in baboon and human ocular tissues: cornea, lens, uvea, and retina

Background Olfactomedin‐like is a family of polyfunctional polymeric glycoproteins. This family has at least four members. One member of this family is OLFML3, which is preferentially expressed in placenta but is also detected in other adult tissues including the liver and heart. However, its orthol...

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Bibliographic Details
Published in:Journal of medical primatology 2013-06, Vol.42 (3), p.105-111
Main Authors: Rodríguez-Sánchez, I.P., Garza-Rodríguez, M.L., Mohamed-Noriega, K., Voruganti, V.S., Tejero, M.E., Delgado-Enciso, I., Pérez-Ibave, D.C., Schlabritz-Loutsevitch, N.E., Mohamed-Noriega, J., Martinez-Fierro, M.L., Reséndez-Pérez, D., Cole, S.A., Cavazos-Adame, H., Comuzzie, A.G., Mohamed-Hamsho, J., Barrera-Saldaña, H.A.
Format: Article
Language:English
Subjects:
Adolescent
Aged
Aged, 80 and over
Amino Acid Sequence
animal model
Animals
Child
Cloning, Molecular
corneal vascularization
DNA, Complementary - genetics
DNA, Complementary - metabolism
eye
Eye - metabolism
gene expression
Glycoproteins - genetics
Glycoproteins - metabolism
Humans
Male
Middle Aged
Molecular Sequence Data
Old World Monkey
Olfactomedin
Organ Specificity
Papio
Papio hamadryas - genetics
Papio hamadryas - metabolism
Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sequence Alignment
Spain
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Summary:Background Olfactomedin‐like is a family of polyfunctional polymeric glycoproteins. This family has at least four members. One member of this family is OLFML3, which is preferentially expressed in placenta but is also detected in other adult tissues including the liver and heart. However, its orthologous rat gene is expressed in the iris, sclera, trabecular meshwork, retina, and optic nerve. Methods OLFML3 messenger amplification was performed by RT‐PCR from human and baboon ocular tissues. The products were cloned and sequenced. Results We report OLFML3 expression in human and baboon eye. The full coding DNA sequence has 1221 bp, from which an open reading frame of 406 amino acid was obtained. The baboon OLFML3 gene nucleotidic sequence has 98% and amino acidic 99% similarity with humans. Conclusions OLFML3 gene expression in human and baboon ocular tissues and its high similarity make the baboon a powerful model to deduce the physiological and/or metabolic function of this protein in the eye.
ISSN:0047-2565
1600-0684
DOI:10.1111/jmp.12037