InterMOD: integrated data and tools for the unification of model organism research

Model organisms are widely used for understanding basic biology, and have significantly contributed to the study of human disease. In recent years, genomic analysis has provided extensive evidence of widespread conservation of gene sequence and function amongst eukaryotes, allowing insights from mod...

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Bibliographic Details
Published in:Scientific reports 2013-05, Vol.3 (1), p.1802-1802, Article 1802
Main Authors: Sullivan, Julie, Karra, Kalpana, Moxon, Sierra A T, Vallejos, Andrew, Motenko, Howie, Wong, J D, Aleksic, Jelena, Balakrishnan, Rama, Binkley, Gail, Harris, Todd, Hitz, Benjamin, Jayaraman, Pushkala, Lyne, Rachel, Neuhauser, Steven, Pich, Christian, Smith, Richard N, Trinh, Quang, Cherry, J Michael, Richardson, Joel, Stein, Lincoln, Twigger, Simon, Westerfield, Monte, Worthey, Elizabeth, Micklem, Gos
Format: Article
Language:English
Subjects:
Animal models
Animals
Conserved sequence
Data processing
Databases, Factual
Databases, Genetic
Eukaryotes
Genome
Genomic analysis
Genomics - methods
Models, Genetic
Organisms
Species
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Summary:Model organisms are widely used for understanding basic biology, and have significantly contributed to the study of human disease. In recent years, genomic analysis has provided extensive evidence of widespread conservation of gene sequence and function amongst eukaryotes, allowing insights from model organisms to help decipher gene function in a wider range of species. The InterMOD consortium is developing an infrastructure based around the InterMine data warehouse system to integrate genomic and functional data from a number of key model organisms, leading the way to improved cross-species research. So far including budding yeast, nematode worm, fruit fly, zebrafish, rat and mouse, the project has set up data warehouses, synchronized data models, and created analysis tools and links between data from different species. The project unites a number of major model organism databases, improving both the consistency and accessibility of comparative research, to the benefit of the wider scientific community.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep01802