The impact of adolescent social isolation on dopamine D2 and cannabinoid CB1 receptors in the adult rat prefrontal cortex

Highlights ► Isolation-reared adult rats show a reduction in PFC dendritic dopamine D2 receptors. ► Cannabinoid CB1 receptor signaling may locally mitigate this D2 receptor decrease. ► A sensory motor gating deficit is also evident in isolation-reared adult rats.

Saved in:
Bibliographic Details
Published in:Neuroscience 2013-04, Vol.235, p.40-50
Main Authors: Fitzgerald, M.L, Mackie, K, Pickel, V.M
Format: Article
Language:English
Subjects:
Acoustic Stimulation
adolescence
Adult and adolescent clinical studies
Animals
Biological and medical sciences
Data Interpretation, Statistical
Dendrites - metabolism
Dendrites - physiology
Dendrites - ultrastructure
dopamine
electron microscopy
Immunoenzyme Techniques
Immunohistochemistry
isolation rearing
Male
Medical sciences
Microscopy, Electron, Transmission
Microscopy, Immunoelectron
Neurology
Neurons - metabolism
Neurons - ultrastructure
Neuropharmacology
Pharmacology. Drug treatments
prefrontal cortex (PFC)
Prefrontal Cortex - metabolism
Prefrontal Cortex - physiology
Prefrontal Cortex - ultrastructure
Presynaptic Terminals - metabolism
Presynaptic Terminals - physiology
Presynaptic Terminals - ultrastructure
Psychodysleptics: hallucinogen
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychoses
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 - physiology
Receptors, Dopamine D2 - physiology
Receptors, Presynaptic - physiology
Receptors, Presynaptic - ultrastructure
Reflex, Startle
Schizophrenia
Sensory Gating - drug effects
Sensory Gating - physiology
Social Isolation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Isolation-reared adult rats show a reduction in PFC dendritic dopamine D2 receptors. ► Cannabinoid CB1 receptor signaling may locally mitigate this D2 receptor decrease. ► A sensory motor gating deficit is also evident in isolation-reared adult rats.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.01.021