Illuminating regeneration: noninvasive imaging of disease progression in muscular dystrophy

Muscular dystrophies are characterized by progressive muscle weakness and wasting. Among the key obstacles to the development of therapies is the absence of an assay to monitor disease progression in live animals. In this issue of the JCI, Maguire and colleagues use noninvasive bioluminescence imagi...

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Bibliographic Details
Published in:The Journal of clinical investigation 2013-05, Vol.123 (5), p.1931-1934
Main Authors: Levy, Jennifer R, Campbell, Kevin P
Format: Article
Language:English
Subjects:
Animals
Biomedical research
Development and progression
Diagnostic imaging
Female
Luminescent Measurements - methods
Male
Methods
Muscular Dystrophies - diagnosis
Muscular dystrophy
Muscular system
Proteins
Regeneration (Biology)
Rodents
Studies
Citations: Items that this one cites
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Summary:Muscular dystrophies are characterized by progressive muscle weakness and wasting. Among the key obstacles to the development of therapies is the absence of an assay to monitor disease progression in live animals. In this issue of the JCI, Maguire and colleagues use noninvasive bioluminescence imaging to monitor luciferase activity in mice expressing an inducible luciferase reporter gene in satellite cells. These cells proliferate in response to degeneration, therefore increasing the level of luciferase expression in dystrophic muscle.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI69568