Increased space-bandwidth product in pixel super-resolved lensfree on-chip microscopy

Pixel-size limitation of lensfree on-chip microscopy can be circumvented by utilizing pixel-super-resolution techniques to synthesize a smaller effective pixel, improving the resolution. Here we report that by using the two-dimensional pixel-function of an image sensor-array as an input to lensfree...

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Bibliographic Details
Published in:Scientific reports 2013-04, Vol.3 (1), p.1717, Article 1717
Main Authors: Greenbaum, Alon, Luo, Wei, Khademhosseinieh, Bahar, Su, Ting-Wei, Coskun, Ahmet F., Ozcan, Aydogan
Format: Article
Language:English
Subjects:
Image processing
Microscopy
Nanotubes
Sensors
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Summary:Pixel-size limitation of lensfree on-chip microscopy can be circumvented by utilizing pixel-super-resolution techniques to synthesize a smaller effective pixel, improving the resolution. Here we report that by using the two-dimensional pixel-function of an image sensor-array as an input to lensfree image reconstruction, pixel-super-resolution can improve the numerical aperture of the reconstructed image by ~3 fold compared to a raw lensfree image. This improvement was confirmed using two different sensor-arrays that significantly vary in their pixel-sizes, circuit architectures and digital/optical readout mechanisms, empirically pointing to roughly the same space-bandwidth improvement factor regardless of the sensor-array employed in our set-up. Furthermore, such a pixel-count increase also renders our on-chip microscope into a Giga-pixel imager, where an effective pixel count of ~1.6-2.5 billion can be obtained with different sensors. Finally, using an ultra-violet light-emitting-diode, this platform resolves 225 nm grating lines and can be useful for wide-field on-chip imaging of nano-scale objects, e.g., multi-walled-carbon-nanotubes.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep01717