Which part of the Quick mild cognitive impairment screen (Qmci) discriminates between normal cognition, mild cognitive impairment and dementia?

the Qmci is a sensitive and specific test to differentiate between normal cognition (NC), mild cognitive impairment (MCI) and dementia. We compared the sensitivity and specificity of the subtests of the Qmci to determine which best discriminated NC, MCI and dementia. the objective was to determine t...

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Bibliographic Details
Published in:Age and ageing 2013-05, Vol.42 (3), p.324-330
Main Authors: O'Caoimh, Rónán, Gao, Yang, Gallagher, Paul Francis, Eustace, Joesph, McGlade, Ciara, Molloy, D William
Format: Article
Language:English
Subjects:
Academic achievement
Aged
Area Under Curve
Case-Control Studies
Chi-Square Distribution
Cognition
Cognition disorders in old age
Cognitive ability
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - psychology
Cognitive impairment
Cognitive tests
Comparative analysis
Dementia
Dementia - diagnosis
Dementia - psychology
Diagnosis
Diagnosis, Differential
Executive Function
Female
Fluency
Geriatric cognitive disorders
Humans
Male
Medical tests
Memory
Mental health
Neuropsychological Tests
Predictive Value of Tests
Psychomotor Performance
Research Papers
ROC Curve
Sensitivity
Sensitivity analysis
Testing
User statistics
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Summary:the Qmci is a sensitive and specific test to differentiate between normal cognition (NC), mild cognitive impairment (MCI) and dementia. We compared the sensitivity and specificity of the subtests of the Qmci to determine which best discriminated NC, MCI and dementia. the objective was to determine the contribution each subtest of the Qmci makes, to its sensitivity and specificity in differentiating MCI from NC and dementia, to refine and shorten the instrument. existing data from our previous study of 965 subjects, testing the Qmci, was analysed to compare the sensitivity and specificity of the Qmci subtests. all the subtests of the Qmci differentiated MCI from NC. Logical memory (LM) performed the best (area under the receiver operating curve of 0.80), registration the worst, (0.56). LM and verbal fluency had the largest median differences (expressed as percentage of total score) between MCI and NC, 20 and 25%, respectively. Other subtests did not have clinically useful differences. LM was best at differentiating MCI from NC, irrespective of age or educational status. the Qmci incorporates several important cognitive domains making it useful across the spectrum of cognitive impairment. LM is the best performing subtest for differentiating MCI from NC.
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/aft044