Anti-anaphylactic and anti-inflammatory activities of a bioactive alkaloid from the root bark of Plumeria acutifolia Poir

Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive c...

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Bibliographic Details
Published in:Asian Pacific journal of tropical biomedicine 2011-10, Vol.1 (5), p.401-405
Main Authors: Vijayalakshmi, A, Ravichandiran, V, Velraj, Malarkodi, Hemalatha, S, Sudharani, G, Jayakumari, S
Format: Article
Language:English
Subjects:
activity
acutifolia
Anaphylaxis - drug therapy
Animals
Anti-Allergic Agents - chemistry
Anti-Allergic Agents - pharmacology
Anti-Allergic Agents - therapeutic use
Anti-anaphylactic
Anti-inflammatory
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti–inflammatory activity
Apocynaceae - chemistry
Disease Models, Animal
Erythrocyte Membrane - drug effects
Erythrocytes
Female
Inflammatory
Inflammatory mediator
Iridoids - chemistry
Iridoids - pharmacology
Iridoids - therapeutic use
Male
mediator
Membrane
Membrane stabilizing
Mice
Original
Plant Bark - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plumeria
Plumeria acutifolia
Plumerianine
Rats, Wistar
stabilizing
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Summary:Objective:To investigate the anti-anaphylactic,anti-inflammatory and membrane stabilizing properties of plumerianine(compound 1)isolated from the root bark of Plumeria acuifolia Poir.Methods:The anti-anaphylactic activity of compound 1(10,25 and 50 mg/kg)was studied by using models such as passive cutaneous anaphylaxis,passive paw anaphylaxis and its antiinflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats was also investigated using ketotifen and indomethacin as reference drugs.Results:A dose-dependent beneficial effect was observed on leakage of evans blue dye in skin challenged with antigen and on paw anaphylaxis induced by antiserum.The compound 1 also exhibited significant(P<0.01)inhibition of rat paw edema and granuloma tissue formation,including significant protection of RBC against the haemolytic effect of hypotonic solution,an indication of membrane-stabilizing activity.Conclusions:Anti-anaphylactic activity of compound 1 may be possibly due to inhibition of the release of various inflammatory mediators.Anti-inflammatory activity of compound may be related to the inhibition of the early phase and late phase of inflammatory events.
ISSN:2221-1691
2588-9222
DOI:10.1016/S2221-1691(11)60088-9