Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats

To investigate the antidiabetic property of Merremia emarginata (M. emarginata) Burm. F. plant in streptozotocin induced diabetic rats. The dose dependent effects of 28 days oral treatment with methanol extract (100, 200 and 400 mg/kg) from the plant of M. emarginata on blood glucose level, body wei...

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Bibliographic Details
Published in:Asian Pacific journal of tropical biomedicine 2012-04, Vol.2 (4), p.281-286
Main Authors: Gandhi, G Rajiv, Sasikumar, P
Format: Article
Language:English
Subjects:
Animals
Antidiabetic effect
Blood glucose
Blood Glucose - drug effects
Body Weight - drug effects
Carbohydrate metabolizing enzymes
Convolvulaceae - chemistry
Diabetes mellitus
Diabetes Mellitus, Experimental - metabolism
Histology
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - pharmacology
Insulin
Insulin - blood
Male
Merremia emarginata
Original
Plant Extracts - chemistry
Plant Extracts - pharmacology
Rats
Rats, Wistar
Streptozotocin
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Summary:To investigate the antidiabetic property of Merremia emarginata (M. emarginata) Burm. F. plant in streptozotocin induced diabetic rats. The dose dependent effects of 28 days oral treatment with methanol extract (100, 200 and 400 mg/kg) from the plant of M. emarginata on blood glucose level, body weight, insulin, total hemoglobin, glycosylated haemoglobin (HbA1C), total protein, serum urea, serum creatinine and carbohydrate metabolizing enzymes were evaluated in streptozotocin induced diabetic rats. Histology of pancreas was also studied. A significant decrease in blood glucose, serum urea and serum creatinine and significant increase in body weight, insulin and protein level were observed in diabetic rats treated with M. emarginata. Treatment with M. emarginata resulted in a significant reduction of HbA1C and an increase in total hemoglobin level. The activities of carbohydrate metabolizing enzymes such as hexokinase were significantly increased whereas glucose-6-phosphatase, fructose-1, 6-bisphosphatase were significantly decreased by the administration of M. emarginata in diabetic rats. Histology of diabetic rats treated with M. emarginata showed the pancreatic β-cells regeneration. These findings suggest that M. emarginata has potent antidiabetic activity in streptozotocin induced diabetic rats.
ISSN:2221-1691
2588-9222
DOI:10.1016/S2221-1691(12)60023-9