Association of elevated cytokines with childhood adversity in a sample of healthy adults

Abstract Objective Childhood trauma has been associated adult stress-related disorders. However, little is known about physiologic alterations in adults with a history of early life trauma that do not have current psychiatric or medical diagnoses. In this study, the relationships between childhood a...

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Bibliographic Details
Published in:Journal of psychiatric research 2013-05, Vol.47 (5), p.604-610
Main Authors: Hartwell, Karen J, Moran-Santa Maria, Megan M, Twal, Waleed O, Shaftman, Stephanie, DeSantis, Stacia M, McRae-Clark, Aimee L, Brady, Kathleen T
Format: Article
Language:English
Subjects:
Adult
Adversity
Biological and medical sciences
Biological stress
C-reactive protein
C-Reactive Protein - metabolism
Child
Child Abuse - psychology
Childhood
Childhood abuse
Cytokines
Cytokines - blood
Depressive Disorder, Major - blood
Depressive Disorder, Major - physiopathology
Female
Humans
Innate immunity
Life Change Events
Life stress
Linear Models
Longitudinal Studies
Male
Medical sciences
Physical Examination
Psychiatric disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Stress
Stress Disorders, Post-Traumatic - blood
Stress Disorders, Post-Traumatic - physiopathology
Stress, Psychological - blood
Traumatic life events
Young Adult
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Summary:Abstract Objective Childhood trauma has been associated adult stress-related disorders. However, little is known about physiologic alterations in adults with a history of early life trauma that do not have current psychiatric or medical diagnoses. In this study, the relationships between childhood adversity and cytokine and C-reactive protein (CRP) levels in healthy adults were examined. Method Participants included men ( n  = 18) and women ( n  = 20) who did not meet DSM-IV criteria for Axis I psychiatric disorders or any major medical illness. Cytokine and CRP levels were obtained from baseline blood samples. Subjects completed the Early Trauma Inventory Self Report (ETI-SR). The primary outcomes included serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL1-β), and CRP levels. In addition, the mean numbers of traumatic experiences (sexual, physical, emotional, general, and the summed total) were measured. Results Significant positive associations were found between the total ETI score and IL-6 ( p  = 0.05), IL1-β ( p  
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2013.01.008