Potentially-toxic and essential elements profile of AH1N1 patients in Mexico City

During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different...

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Bibliographic Details
Published in:Scientific reports 2013-02, Vol.3 (1), p.1284, Article 1284
Main Authors: Moya, Mireya, Bautista, Edgar G, Velázquez-González, Antonio, Vázquez-Gutiérrez, Felipe, Tzintzun, Guadalupe, García-Arreola, María Elena, Castillejos, Manuel, Hernández, Andrés
Format: Article
Language:English
Subjects:
Adult
Arsenic
Arsenic - blood
Blood levels
Cadmium
Cadmium - blood
Case-Control Studies
Chromium
Female
Glutathione peroxidase
Glutathione Peroxidase - blood
Humans
Illnesses
Influenza
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza, Human - blood
Influenza, Human - epidemiology
Influenza, Human - virology
Lead
Lead - blood
Male
Mercury
Mercury - blood
Metals - blood
Mexico
Middle Aged
Pandemics
Pneumonia
Pneumonia - blood
Pneumonia - diagnosis
Respiratory diseases
Selenium
Selenium - blood
Young Adult
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Summary:During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls, both not infected with the pandemic strain. Significant concentrations of potentially-toxic elements (lead, mercury, cadmium, chromium, arsenic) along with deficiency of selenium or increased Zn/Cu ratios characterized AH1N1 cases under study when evaluated versus controlled cases. Deficiency of selenium is progressively observed from controls I (influenza like illness) through controls II (pneumonia) and finally pneumonia-AH1N1 infected patients. Cases with blood Se levels greater than the recommended for an optimal cut-off to activate glutathione peroxidase (12.5 μg/dL) recovered from illness and survived. Evaluation of this essential element in critical pneumonia patients at the National Institutes is under evaluation as a clinical trial.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep01284