Observational Study of Once-Daily Insulin Detemir in People with Type 2 Diabetes Aged 75 Years or Older: A Sub-Analysis of Data from the Study of Once-Daily Levemir (SOLVE)

Objectives Older patients are particularly vulnerable to hypoglycaemia. The aim of this study was to evaluate the response to initiation of once-daily insulin detemir in patients aged ≥75 years with type 2 diabetes mellitus (T2DM) treated with one or more oral antidiabetic drugs (OADs). Methods A su...

Full description

Saved in:
Bibliographic Details
Published in:Drugs & aging 2013-03, Vol.30 (3), p.167-175
Main Authors: Karnieli, Eddy, Baeres, Florian M. M., Dzida, Grzegorz, Ji, Qiuhe, Ligthelm, Robert, Ross, Stuart, Svendsen, Anne Louise, Yale, Jean-François
Format: Article
Language:English
Subjects:
Age groups
Aged
Antidiabetics
Biological and medical sciences
Blood Glucose - analysis
Clinical medicine
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Geriatrics/Gerontology
Glucose
Glycated Hemoglobin A - analysis
Health care expenditures
Hemoglobin
Hormones. Endocrine system
Humans
Hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - adverse effects
Insulin
Insulin Detemir
Insulin, Long-Acting - administration & dosage
Insulin, Long-Acting - adverse effects
Internal Medicine
Life expectancy
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Morbidity
Observational studies
Older people
Original
Original Research Article
Patients
Pharmacology. Drug treatments
Pharmacology/Toxicology
Pharmacotherapy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Older patients are particularly vulnerable to hypoglycaemia. The aim of this study was to evaluate the response to initiation of once-daily insulin detemir in patients aged ≥75 years with type 2 diabetes mellitus (T2DM) treated with one or more oral antidiabetic drugs (OADs). Methods A sub-analysis was conducted using data from SOLVE (Study of Once daily LeVEmir), a 24-week observational study involving 3,219 investigators and 2,817 project sites from ten countries. Routine clinical practice was followed; there were no study-prescribed procedures. The total cohort comprised 17,374 participants, of whom 2,398 (14 %) were aged ≥75 years. The physicians collected information from patient recall, the patients’ medical records and their self-monitored blood glucose diaries (if kept). Results Pre-insulin glycated haemoglobin (HbA 1c ) was similar between participants aged ≥75 years and those aged
ISSN:1170-229X
1179-1969
DOI:10.1007/s40266-013-0054-3