Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis

Summary Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c+ myeloid dendritic cells to promote T helper type 2 (Th2)‐skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis...

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Bibliographic Details
Published in:Clinical and experimental immunology 2013-03, Vol.171 (3), p.330-337
Main Authors: Sano, Y., Masuda, K., Tamagawa‐Mineoka, R., Matsunaka, H., Murakami, Y., Yamashita, R., Morita, E., Katoh, N.
Format: Article
Language:English
Subjects:
Adult
Antibodies
Atopic dermatitis
atopy
Biomarkers
Body Water - metabolism
CD11c antigen
CD4 T cells (Th2)
Cytokines - biosynthesis
Cytokines - metabolism
Dendritic cells
Dermatitis
Dermatitis, Atopic - metabolism
Dermatitis, Atopic - pathology
Female
Humans
Hydration
Image processing
Inflammation
Kallikreins - genetics
Male
Medical research
Middle Aged
Original
Severity of Illness Index
Skin - metabolism
Skin diseases
skin immunology/disease
Stratum corneum
Thymic stromal lymphopoietin
Water loss
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Summary:Summary Thymic stromal lymphopoietin (TSLP) is known for its capacity to induce CD11c+ myeloid dendritic cells to promote T helper type 2 (Th2)‐skewed inflammatory responses. Although increased expression of TSLP was reported in the lesional skin of limited numbers of patients with atopic dermatitis (AD), the relationships between the degree of TSLP expression in the skin and the severity of AD, epidermal barrier function and eruption type remain to be elucidated. The aim of this study was to examine the relationships between the degree of TSLP expression in the skin and the severity of AD, eruption type and epidermal barrier function using a non‐invasive method in a sizeable group of the patients. Stratum corneum tissue was obtained from AD patients by tape stripping, and the stratum corneum TSLP (scTSLP) expression level was evaluated using a TSLP‐specific antibody followed by image analysis. The correlations between the scTSLP intensity and the severity scoring of AD (SCORAD) index and epidermal barrier function, such as stratum corneum hydration and transepidermal water loss (TEWL), were analysed. The changes in the scTSLP level induced by the application of moisturizer were also examined. The scTSLP expression level was increased in AD patients compared with healthy subjects and was correlated with SCORAD, especially with the dry skin score, and stratum corneum hydration. Moisturizer application resulted in reduced scTSLP levels. The scTSLP level can be used as a biomarker of AD severity and particularly epidermal barrier status.
ISSN:0009-9104
1365-2249
DOI:10.1111/cei.12021