Management and Recurrence Patterns of Desmoids Tumors: A Multi-institutional Analysis of 211 Patients

Background Desmoid tumors are rare soft-tissue neoplasms with limited data on their management. We sought to determine the rates of recurrence following surgery for desmoid tumors and identify factors predictive of disease-free survival. Methods Between January 1983 and December 2011, 211 patients w...

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Bibliographic Details
Published in:Annals of surgical oncology 2012-12, Vol.19 (13), p.4036-4042
Main Authors: Peng, Peter D., Hyder, Omar, Mavros, Michael N., Turley, Ryan, Groeschl, Ryan, Firoozmand, Amin, Lidsky, Michael, Herman, Joseph M., Choti, Michael, Ahuja, Nita, Anders, Robert, Blazer, Daniel G., Gamblin, T. Clark, Pawlik, Timothy M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Bone and Soft Tissue Sarcomas
Child
Child, Preschool
Female
Fibromatosis, Abdominal - mortality
Fibromatosis, Abdominal - pathology
Fibromatosis, Abdominal - surgery
Fibromatosis, Aggressive - mortality
Fibromatosis, Aggressive - pathology
Fibromatosis, Aggressive - surgery
Follow-Up Studies
Humans
Infant
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Oncology
Postoperative Complications
Prognosis
Surgery
Surgical Oncology
Survival Rate
Young Adult
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Summary:Background Desmoid tumors are rare soft-tissue neoplasms with limited data on their management. We sought to determine the rates of recurrence following surgery for desmoid tumors and identify factors predictive of disease-free survival. Methods Between January 1983 and December 2011, 211 patients with desmoid tumors were identified from three major surgical centers. Clinicopathologic and treatment characteristics were analyzed to identify predictors of recurrence. Results Median age was 36 years; patients were predominantly female (68 %). Desmoid tumors most commonly arose in extremities (32 %), abdominal cavity (23 %) or wall (21 %), and thorax (15 %); median size was 7.5 cm. Most patients had an R0 surgical margin (60 %). The 1- and 5-year recurrence-free survival was 81.3 and 52.8 %, respectively. Factors associated with worse recurrence-free survival were: younger age (for each 5-year increase in age, hazard ratio [HR] = 0.90, 95 % confidence interval [95 % CI] 0.82–0.98) and extra-abdominal tumor location (abdominal wall referent: extra-abdominal site, HR = 3.28, 95 % CI, 1.46–7.36) (both P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-012-2634-6