Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

A major unanswered question in neuroscience is whether there exists genomic variability between individual neurons of the brain, contributing to functional diversity or to an unexplained burden of neurological disease. To address this question, we developed a method to amplify genomes of single neur...

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Bibliographic Details

Published in:	Cell 2012-10, Vol.151 (3), p.483-496
Main Authors:	Evrony, Gilad D., Cai, Xuyu, Lee, Eunjung, Hills, L. Benjamin, Elhosary, Princess C., Lehmann, Hillel S., Parker, J.J., Atabay, Kutay D., Gilmore, Edward C., Poduri, Annapurna, Park, Peter J., Walsh, Christopher A.
Format:	Article
Language:	eng
Subjects:	Caudate Nucleus - cytology Caudate Nucleus - metabolism cerebral cortex Cerebral Cortex - cytology Cerebral Cortex - metabolism Child children Chromosomes, Human, Pair 18 cortex functional diversity genome Genome-Wide Association Study genomes genomics germ cells Humans Long Interspersed Nucleotide Elements Male Malformations of Cortical Development - genetics Malformations of Cortical Development - pathology Mosaicism Mutation nervous system diseases neurons Neurons - metabolism neurophysiology Proto-Oncogene Proteins c-akt - genetics sequence analysis Single-Cell Analysis somatic mutation Trisomy
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