Metabolic syndrome and left ventricular function: is the number of criteria actually important?

Metabolic syndrome (MS) is a clustering of cardiovascular risk factors responsible for the development of target organ damage. The aim of this study was to determine the effect of the increasing number of MS risk factors on left ventricular function assessed by noninvasive methods. The study include...

Full description

Saved in:
Bibliographic Details
Published in:Medical science monitor 2012-05, Vol.18 (5), p.CR282-CR289
Main Authors: Tadic, Marijana, Ivanovic, Branislava, Kostic, Nada, Simic, Dragan, Matic, Danica, Celic, Vera
Format: Article
Language:English
Subjects:
Clinical Research
Cross-Sectional Studies
Echocardiography, Doppler
Female
Heart Function Tests
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Male
Metabolic Syndrome - physiopathology
Middle Aged
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolic syndrome (MS) is a clustering of cardiovascular risk factors responsible for the development of target organ damage. The aim of this study was to determine the effect of the increasing number of MS risk factors on left ventricular function assessed by noninvasive methods. The study included 204 subjects with MS and 76 controls with no MS risk factors. MS was defined by the presence of 3 or more of ATP-NCEP III criteria. MS subjects were grouped according to the number of criteria they fulfilled: 3 criteria (n=91), 4 criteria (n=65) and 5 criteria (n=48). All subjects underwent laboratory blood tests, complete 2-dimensional, pulse and tissue Doppler echocardiography. Echocardiography was used to assess systolic (LVEF, sseptal), diastolic function, by pulse-wave Doppler (E/A ratio) and tissue Doppler imaging (E/e'average), and global left ventricular function (Tei index). Appropriate time intervals for the estimation of the Tei index were obtained by tissue Doppler. Transmitral E/A ratio decreased significantly and progressively from the 3 criteria to the 5 criteria group (0.82 ± 0.25 vs. 0.79 ± 0.24 vs. 0.67 ± 0.14, p
ISSN:1234-1010
1643-3750
DOI:10.12659/MSM.882733