SUMO: A Multifaceted Modifier of Chromatin Structure and Function

A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of ch...

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Bibliographic Details
Published in:Developmental cell 2013-01, Vol.24 (1), p.1-12
Main Authors: Cubeñas-Potts, Caelin, Matunis, Michael J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Chromatin
Chromatin - chemistry
Chromatin - genetics
Chromatin - metabolism
Chromatin. Chromosome
DNA
Fundamental and applied biological sciences. Psychology
Gene expression
Genomes
Histones
Humans
Molecular and cellular biology
Molecular genetics
Nuclear Proteins - metabolism
Protein Processing, Post-Translational
Reviews
Small Ubiquitin-Related Modifier Proteins - metabolism
Structure-function relationships
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Summary:A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this Review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2012.11.020