Formulation development and evaluation of fast dissolving film of telmisartan

Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient complian...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2012-03, Vol.74 (2), p.122-126
Main Authors: Londhe, Vaishali Y, Umalkar, Kashmira B
Format: Article
Language:English
Subjects:
Biopharmaceutics
Drug dosages
Hydroxypropyl cellulose
Pharmaceuticals
Pharmacology
Properties
Research Paper
Tablets (Medicine)
Telmisartan
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Summary:Hypertension is a major cause of concern not just in the elderly but also in the youngsters. An effort was made to formulate a fast dissolving film containing telmisartan which is used in the treatment of hypertension with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The major challenge in formulation of oral films of telmisatran is that it shows very less solubility in the pH range of 3-9. Various film forming agents and polyhydric alcohols were evaluated for optimizing composition of fast dissolving films. Fast dissolving films using hydroxypropyl methylcellulose, polyvinyl alcohol, glycerol, sorbitol, menthol and an alkalizer were formulated using solvent casting method. Optimized formulations were evaluated for their weight, thickness, folding endurance, appearance, tensile strength, disintegration time and dissolution profile.
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.10384