Comparison of children with onset of juvenile dermatomyositis symptoms before or after their fifth birthday in a UK and Ireland juvenile dermatomyositis cohort study

Objective To compare 2 groups of children with juvenile dermatomyositis (DM), those with onset of symptoms before their fifth birthday versus those whose disease begins either on or after their fifth birthday, and to assess whether age at onset is associated with differences in disease presentation,...

Full description

Saved in:
Bibliographic Details
Published in:Arthritis care & research (2010) 2012-11, Vol.64 (11), p.1665-1672
Main Authors: Martin, N., Krol, P., Smith, S., Beard, L., Pilkington, C. A., Davidson, J., Wedderburn, L. R.
Format: Article
Language:English
Subjects:
Adolescent
Age Distribution
Age of Onset
Alopecia - epidemiology
Biological and medical sciences
Child
Child, Preschool
Cohort Studies
Dermatomyositis - epidemiology
Dermatomyositis - pathology
Disease Progression
Diseases of the osteoarticular system
Female
Follow-Up Studies
Headache - epidemiology
Humans
Incidence
Infant
Ireland - epidemiology
Male
Medical sciences
Pediatric Rheumatology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Skin Ulcer - epidemiology
Skin Ulcer - pathology
United Kingdom - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To compare 2 groups of children with juvenile dermatomyositis (DM), those with onset of symptoms before their fifth birthday versus those whose disease begins either on or after their fifth birthday, and to assess whether age at onset is associated with differences in disease presentation, treatments received, or outcomes 2 years after diagnosis. Methods Data were analyzed on children recruited to a UK juvenile DM cohort study with a diagnosis of probable or definite juvenile DM and less than 12 months between diagnosis and recruitment. Results Fifty‐five (35%) of 157 children had onset of symptoms before their fifth birthday. At diagnosis, cutaneous ulceration was found in 32.7% of the younger group versus 11.8% of the older group (P = 0.003). Facial or body swelling was reported more often in the younger group, whereas headaches, alopecia, and Raynaud's phenomenon were all more frequently reported in the older group. At followup 2 years later, there were no important differences in outcomes between the groups. More than 90% of patients in both groups received both methotrexate and steroids. Twenty‐three percent of both groups remained on steroids 2 years after diagnosis. Conclusion Our study showed that children with juvenile DM with disease onset at age
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.21753