F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex

Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted by myosin thick filaments. Myosin motors generate both compressive and tensile stresses on F-actin and consequently ind...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2012-12, Vol.109 (51), p.20820-20825
Main Authors: Murrell, Michael P., Gardel, Margaret L.
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - metabolism
Actins
Actins - metabolism
Actomyosin - chemistry
Adhesion
Animals
Bending
Biochemistry
Biological Sciences
Biomimetics
Buckling
Cell Adhesion
Cell adhesion & migration
Cell membranes
Chickens
Compressive Strength
Compressive stress
Curvature
Cytoskeleton - metabolism
Dimerization
Lipid Bilayers - chemistry
Membranes
Microfilaments
Muscle Contraction - physiology
Muscle, Smooth - cytology
Myosin Type II - metabolism
Ovum
Physical Sciences
Protein Binding
Protein Structure, Tertiary
Proteins
Radius of curvature
Stress response
Stress, Mechanical
Tensile stress
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Summary:Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted by myosin thick filaments. Myosin motors generate both compressive and tensile stresses on F-actin and consequently induce large bending fluctuations, which reduces their effective persistence length to
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1214753109