Patient selection criteria for blastocyst transfers in extended embryo culture programs

Purpose To identify the correlation between different cycles, patient factors and blastocyst characteristics. Methods The study included 420 patients undergoing ICSI cycles and 2781 graded blastocysts, which took into account the blastocyst quality. The correlations between the blastocyst parameters...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2012-12, Vol.29 (12), p.1357-1362
Main Authors: Braga, Daniela Paes Almeida Ferreira, Setti, Amanda S, de Cássia S. Figueira, Rita, Machado, Rogério Bonassi, Iaconelli, Assumpto, Borges, Edson
Format: Article
Language:English
Subjects:
Assisted Reproduction Technologies
Blastocyst - cytology
Body mass index
Cysts
Embryo Culture Techniques - methods
Embryo Transfer
Embryonic Development
Embryos
Female
Fertilization in Vitro
Gynecology
Human Genetics
Humans
Maternal Age
Medicine
Medicine & Public Health
Morphology
Oocytes - cytology
Ovaries
Ovulation Induction
Patient Selection
Patients
Pregnancy
Reproductive Medicine
Sperm
Sperm Injections, Intracytoplasmic
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Summary:Purpose To identify the correlation between different cycles, patient factors and blastocyst characteristics. Methods The study included 420 patients undergoing ICSI cycles and 2781 graded blastocysts, which took into account the blastocyst quality. The correlations between the blastocyst parameters and the patient and cycle characteristics were assessed. Results The blastocyst development was negatively correlated with the maternal age, BMI and dose of FSH. The ICM was negatively correlated with the FSH dose, whereas the TE quality was influenced by the FSH dose, the maternal age and the number of retrieved oocytes. The embryo morphology on days two and three may predict the blastocyst developmental competence. Conclusions Older patients and patients with high BMI should not be included in extended embryo culture programmes. The extended culture may not favour embryos with poor morphology on days two and three of development. Additionally, a lower ovarian stimulation and decreased oocyte yields may lead to the development of high-quality blastocysts.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-012-9875-y