The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats

The purpose of this paper is to study pharmacokinetics of cortisone (E) and its metabolite cortisol (F) in rats after administration of glycyrrhetinic acid (GA) and cortisone. Healthy male SD rats were randomized to be given 20 mg/kg E or E combined with 10 mg/kg GA. Blood samples were collected at...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-5
Main Authors: Hu, Guo-Xin, Ge, Ren-Shan, Wang, Shuang-Hu, Chen, Xiao-Le, Chen, Lian-Guo, Wang, Zhe, Sun, Wei, Lin, Dan, Li, Wan-Shu
Format: Article
Language:English
Subjects:
Acids
Animals
Biomedical research
Calibration
Chromatography
Chromatography, High Pressure Liquid
Computer programs
Cortisone
Cortisone - pharmacokinetics
Glycyrrhetinic Acid - administration & dosage
Glycyrrhetinic Acid - pharmacology
Hydrocortisone - metabolism
Hydrocortisone - pharmacokinetics
Laboratory animals
Male
Quality control
Rats
Rats, Sprague-Dawley
Reference Standards
Reproducibility of Results
Rodents
Time Factors
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Summary:The purpose of this paper is to study pharmacokinetics of cortisone (E) and its metabolite cortisol (F) in rats after administration of glycyrrhetinic acid (GA) and cortisone. Healthy male SD rats were randomized to be given 20 mg/kg E or E combined with 10 mg/kg GA. Blood samples were collected at 5, 10, 20, 40, 60, 90, 120, 150, 180, and 240 min after administration. The serum concentrations of E and F were determined by HLPC and pharmacokinetic parameters were calculated using DASver2.0 software. The parameters of AUC(0−t), AUC(0−∞), and Cmax for E in the group of E + GA were significantly higher than those in the group of E (P
ISSN:2314-6133
1110-7243
2314-6141
1110-7251
DOI:10.1155/2012/856324