Dosimetric advantages of generalised equivalent uniform dose-based optimisation on dose―volume objectives in intensity-modulated radiotherapy planning for bilateral breast cancer

We compared and evaluated the differences between two models for treating bilateral breast cancer (BBC): (i) dose-volume-based intensity-modulated radiation treatment (DV plan), and (ii) dose-volume-based intensity-modulated radiotherapy with generalised equivalent uniform dose-based optimisation (D...

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Bibliographic Details
Published in:British journal of radiology 2012-11, Vol.85 (1019), p.1499-1506
Main Authors: LEE, T.-F, TING, H.-M, HUANG, Y.-J, CHEN, H.-C, FANG, F.-M, CHAO, P.-J, WANG, H.-Y, SHIEH, C.-S, HORNG, M.-F, WU, J.-M, YEH, S.-A, CHO, M.-Y, HUANG, E.-Y
Format: Article
Language:English
Subjects:
Adult
Aged
Applied radiobiology (equipment, dosimetry...)
Biological and medical sciences
Biological effects of radiation
Breast Neoplasms - radiotherapy
Female
Fundamental and applied biological sciences. Psychology
Gynecology. Andrology. Obstetrics
Humans
Investigative techniques, diagnostic techniques (general aspects)
Mammary gland diseases
Medical sciences
Middle Aged
Radiotherapy Dosage - standards
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Conformal - methods
Radiotherapy, Conformal - standards
Tissues, organs and organisms biophysics
Tumors
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Summary:We compared and evaluated the differences between two models for treating bilateral breast cancer (BBC): (i) dose-volume-based intensity-modulated radiation treatment (DV plan), and (ii) dose-volume-based intensity-modulated radiotherapy with generalised equivalent uniform dose-based optimisation (DV-gEUD plan). The quality and performance of the DV plan and DV-gEUD plan using the Pinnacle(3) system (Philips, Fitchburg, WI) were evaluated and compared in 10 patients with stage T2-T4 BBC. The plans were delivered on a Varian 21EX linear accelerator (Varian Medical Systems, Milpitas, CA) equipped with a Millennium 120 leaf multileaf collimator (Varian Medical Systems). The parameters analysed included the conformity index, homogeneity index, tumour control probability of the planning target volume (PTV), the volumes V(20 Gy) and V(30 Gy) of the organs at risk (OAR, including the heart and lungs), mean dose and the normal tissue complication probability. Both plans met the requirements for the coverage of PTV with similar conformity and homogeneity indices. However, the DV-gEUD plan had the advantage of dose sparing for OAR: the mean doses of the heart and lungs, lung V(20) (Gy), and heart V(30) (Gy) in the DV-gEUD plan were lower than those in the DV plan (p
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/24112047