Quantitative biology of single neurons

The building blocks of complex biological systems are single cells. Fundamental insights gained from single-cell analysis promise to provide the framework for understanding normal biological systems development as well as the limits on systems/cellular ability to respond to disease. The interplay of...

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Bibliographic Details
Published in:Journal of the Royal Society interface 2012-12, Vol.9 (77), p.3165-3183
Main Authors: Eberwine, James, Lovatt, Ditte, Buckley, Peter, Dueck, Hannah, Francis, Chantal, Kim, Tae Kyung, Lee, Jaehee, Lee, Miler, Miyashiro, Kevin, Morris, Jacqueline, Peritz, Tiina, Schochet, Terri, Spaethling, Jennifer, Sul, Jai-Yoon, Kim, Junhyong
Format: Article
Language:English
Subjects:
Electrophysiology
Gene Expression Regulation
In Situ Hybridization
Ion Channels - physiology
Neurons - cytology
Neurons - physiology
Protein Biosynthesis
Proteomics
Proteomics - methods
Quantitative Biology
Review
Review Articles
Single Cells
Single Neurons
Single-Cell Analysis - methods
Splicing
Stochastic Processes
Transcriptome
Transcriptomics
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Summary:The building blocks of complex biological systems are single cells. Fundamental insights gained from single-cell analysis promise to provide the framework for understanding normal biological systems development as well as the limits on systems/cellular ability to respond to disease. The interplay of cells to create functional systems is not well understood. Until recently, the study of single cells has concentrated primarily on morphological and physiological characterization. With the application of new highly sensitive molecular and genomic technologies, the quantitative biochemistry of single cells is now accessible.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2012.0417