The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease

This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was m...

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Bibliographic Details
Published in:American journal of epidemiology 2012-11, Vol.176 (9), p.794-802
Main Authors: OHUMA, E. O, OKIRO, E. A, OCHOLA, R, SANDE, C. J, CANE, P. A, MEDLEY, G. F, BOTTOMLEY, C, NOKES, D. J
Format: Article
Language:English
Subjects:
Age Factors
Antigens, Viral
Biological and medical sciences
Child, Preschool
Children & youth
Cohort Studies
Epidemiology
Female
General aspects
Human viral diseases
Humans
Incidence
Infant
Infant, Newborn
Infections
Infectious diseases
Kenya - epidemiology
Male
Medical sciences
Miscellaneous
Original Contributions
Public health. Hygiene
Public health. Hygiene-occupational medicine
Regression analysis
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus Infections - virology
Risk Factors
Severity of Illness Index
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
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Summary:This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a "most pragmatic" serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kws257