Combining diffusion-weighted MRI with Gd-EOB-DTPA-enhanced MRI improves the detection of colorectal liver metastases

To compare the diagnostic accuracy of gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI, diffusion-weighted MRI (DW-MRI) and a combination of both techniques for the detection of colorectal hepatic metastases. 72 patients with suspected colorectal liver metastases...

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Bibliographic Details
Published in:British journal of radiology 2012-07, Vol.85 (1015), p.980-989
Main Authors: KOH, D.-M, COLLINS, D. J, WALLACE, T, CHAU, I, RIDDELL, A. M
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cohort Studies
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Contrast Media
Contrast media. Radiopharmaceuticals
Diffusion Magnetic Resonance Imaging - methods
Female
Gadolinium DTPA
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Image Interpretation, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
Liver Neoplasms - diagnosis
Liver Neoplasms - secondary
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Neoplasm Staging - methods
Pharmacology. Drug treatments
Quality Improvement
Retrospective Studies
Sensitivity and Specificity
Tumors
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Summary:To compare the diagnostic accuracy of gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI, diffusion-weighted MRI (DW-MRI) and a combination of both techniques for the detection of colorectal hepatic metastases. 72 patients with suspected colorectal liver metastases underwent Gd-EOB-DTPA MRI and DW-MRI. Images were retrospectively reviewed with unenhanced T(1) and T(2) weighted images as Gd-EOB-DTPA image set, DW-MRI image set and combined image set by two independent radiologists. Each lesion detected was scored for size, location and likelihood of metastasis, and compared with surgery and follow-up imaging. Diagnostic accuracy was compared using receiver operating characteristics and interobserver agreement by kappa statistics. 417 lesions (310 metastases, 107 benign) were found in 72 patients. For both readers, diagnostic accuracy using the combined image set was higher [area under the curve (Az)=0.96, 0.97] than Gd-EOB-DTPA image set (Az=0.86, 0.89) or DW-MRI image set (Az=0.93, 0.92). Using combined image set improved identification of liver metastases compared with Gd-EOB-DTPA image set (p
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/91771639