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Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases
The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatmen...
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Published in: | BioMed research international 2012-01, Vol.2012 (2012), p.1-18 |
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creator | Webre, Jody M. Hill, James M. Nolan, Nicole M. Clement, Christian McFerrin, Harris E. Bhattacharjee, Partha S. Hsia, Victor Neumann, Donna M. Foster, Timothy P. Lukiw, Walter J. Thompson, Hilary W. |
description | The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics. |
doi_str_mv | 10.1155/2012/612316 |
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Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 1110-7251</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2012/612316</identifier><identifier>PMID: 23091352</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Biomedical research ; Deoxyribonucleic acid ; Disease Models, Animal ; DNA ; Eye diseases ; Eye Infections, Viral - physiopathology ; Eye Infections, Viral - virology ; Genomes ; Grants ; Health aspects ; Health sciences ; Herpes Simplex - physiopathology ; Herpes Simplex - virology ; Herpes simplex virus 1 ; Herpesvirus 1, Human - physiology ; Humans ; Infection ; Infections ; Medical research ; Ophthalmology ; Rabbits ; Recurrence ; Review ; Rodents ; Species Specificity ; Studies ; Virus Activation - physiology ; Virus Latency - physiology</subject><ispartof>BioMed research international, 2012-01, Vol.2012 (2012), p.1-18</ispartof><rights>Copyright © 2012 Jody M. Webre et al.</rights><rights>COPYRIGHT 2012 Hindawi Limited</rights><rights>Copyright © 2012 Jody M. Webre et al. Jody M. Webre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2012 Jody M. Webre et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-9ee30ebbe3bd4384b16653f139ad9d4c8212408ef80bdae833b811ffdaa0f5ed3</citedby><cites>FETCH-LOGICAL-c637t-9ee30ebbe3bd4384b16653f139ad9d4c8212408ef80bdae833b811ffdaa0f5ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467953/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467953/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23091352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Van Wijnen, Andre</contributor><creatorcontrib>Webre, Jody M.</creatorcontrib><creatorcontrib>Hill, James M.</creatorcontrib><creatorcontrib>Nolan, Nicole M.</creatorcontrib><creatorcontrib>Clement, Christian</creatorcontrib><creatorcontrib>McFerrin, Harris E.</creatorcontrib><creatorcontrib>Bhattacharjee, Partha S.</creatorcontrib><creatorcontrib>Hsia, Victor</creatorcontrib><creatorcontrib>Neumann, Donna M.</creatorcontrib><creatorcontrib>Foster, Timothy P.</creatorcontrib><creatorcontrib>Lukiw, Walter J.</creatorcontrib><creatorcontrib>Thompson, Hilary W.</creatorcontrib><title>Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. 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physiopathology</topic><topic>Eye Infections, Viral - virology</topic><topic>Genomes</topic><topic>Grants</topic><topic>Health aspects</topic><topic>Health sciences</topic><topic>Herpes Simplex - physiopathology</topic><topic>Herpes Simplex - virology</topic><topic>Herpes simplex virus 1</topic><topic>Herpesvirus 1, Human - physiology</topic><topic>Humans</topic><topic>Infection</topic><topic>Infections</topic><topic>Medical research</topic><topic>Ophthalmology</topic><topic>Rabbits</topic><topic>Recurrence</topic><topic>Review</topic><topic>Rodents</topic><topic>Species Specificity</topic><topic>Studies</topic><topic>Virus Activation - physiology</topic><topic>Virus Latency - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Webre, Jody M.</creatorcontrib><creatorcontrib>Hill, James M.</creatorcontrib><creatorcontrib>Nolan, Nicole M.</creatorcontrib><creatorcontrib>Clement, Christian</creatorcontrib><creatorcontrib>McFerrin, Harris E.</creatorcontrib><creatorcontrib>Bhattacharjee, Partha S.</creatorcontrib><creatorcontrib>Hsia, Victor</creatorcontrib><creatorcontrib>Neumann, Donna M.</creatorcontrib><creatorcontrib>Foster, Timothy P.</creatorcontrib><creatorcontrib>Lukiw, Walter J.</creatorcontrib><creatorcontrib>Thompson, Hilary W.</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>23091352</pmid><doi>10.1155/2012/612316</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Biomedical research Deoxyribonucleic acid Disease Models, Animal DNA Eye diseases Eye Infections, Viral - physiopathology Eye Infections, Viral - virology Genomes Grants Health aspects Health sciences Herpes Simplex - physiopathology Herpes Simplex - virology Herpes simplex virus 1 Herpesvirus 1, Human - physiology Humans Infection Infections Medical research Ophthalmology Rabbits Recurrence Review Rodents Species Specificity Studies Virus Activation - physiology Virus Latency - physiology |
title | Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases |
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