Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatmen...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-18
Main Authors: Webre, Jody M., Hill, James M., Nolan, Nicole M., Clement, Christian, McFerrin, Harris E., Bhattacharjee, Partha S., Hsia, Victor, Neumann, Donna M., Foster, Timothy P., Lukiw, Walter J., Thompson, Hilary W.
Format: Article
Language:English
Subjects:
Animals
Biomedical research
Deoxyribonucleic acid
Disease Models, Animal
DNA
Eye diseases
Eye Infections, Viral - physiopathology
Eye Infections, Viral - virology
Genomes
Grants
Health aspects
Health sciences
Herpes Simplex - physiopathology
Herpes Simplex - virology
Herpes simplex virus 1
Herpesvirus 1, Human - physiology
Humans
Infection
Infections
Medical research
Ophthalmology
Rabbits
Recurrence
Review
Rodents
Species Specificity
Studies
Virus Activation - physiology
Virus Latency - physiology
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Summary:The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.
ISSN:1110-7243
2314-6133
1110-7251
1110-7251
2314-6141
DOI:10.1155/2012/612316