Mosquito immune defenses against Plasmodium infection

The causative agent of malaria, Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. Here we discuss recent findings on the role of the mosquito's innat...

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Bibliographic Details
Published in:Developmental and comparative immunology 2010-04, Vol.34 (4), p.387-395
Main Authors: Cirimotich, Chris M., Dong, Yuemei, Garver, Lindsey S., Sim, Shuzhen, Dimopoulos, George
Format: Article
Language:English
Subjects:
Animals
Anopheles
Culicidae
Culicidae - immunology
Evolution, Molecular
Fibrinogen - immunology
Fibrinogen - metabolism
Gene Expression Regulation, Enzymologic - immunology
Humans
Immunity, Innate
Infection Control
Innate immunity
Insect Proteins - immunology
Insect Vectors - growth & development
Insect Vectors - immunology
Insect Vectors - pathogenicity
Lectins, C-Type - immunology
Malaria
Malaria - immunology
Malaria - parasitology
Malaria - transmission
Mosquito
Oocysts - immunology
Oocysts - metabolism
Plasmodium
Plasmodium berghei - growth & development
Plasmodium berghei - immunology
Plasmodium berghei - pathogenicity
Signal Transduction - immunology
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Summary:The causative agent of malaria, Plasmodium, has to undergo complex developmental transitions and survive attacks from the mosquito's innate immune system to achieve transmission from one host to another through the vector. Here we discuss recent findings on the role of the mosquito's innate immune signaling pathways in preventing infection by the Plasmodium parasite, the identification and mechanistic description of novel anti-parasite molecules, the role that natural bacteria harbored in the mosquito midgut might play in this immune defense and the crucial parasite and vector molecules that mediate midgut infection.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2009.12.005