Design of a High-Throughput Flow Perfusion Bioreactor System for Tissue Engineering

Flow perfusion culture is used in many areas of tissue engineering and offers several key advantages. However, one challenge to these cultures is the relatively low-throughput nature of perfusion bioreactors. Here, a flow perfusion bioreactor with increased throughput was designed and built for tiss...

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Bibliographic Details
Published in:Tissue engineering. Part C, Methods Methods, 2012-10, Vol.18 (10), p.817-820
Main Authors: Dahlin, Rebecca L., Meretoja, Ville V., Ni, Mengwei, Kasper, F. Kurtis, Mikos, Antonios G.
Format: Article
Language:English
Subjects:
Animals
Bioreactors
Cattle
Cell culture
Cell growth
Chondrocytes - cytology
Equipment Design
High-Throughput Screening Assays - instrumentation
Membrane reactors
Perfusion
Perfusion - instrumentation
Perfusion - methods
Rheology
Tissue engineering
Tissue Engineering - instrumentation
Tissue Engineering - methods
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Summary:Flow perfusion culture is used in many areas of tissue engineering and offers several key advantages. However, one challenge to these cultures is the relatively low-throughput nature of perfusion bioreactors. Here, a flow perfusion bioreactor with increased throughput was designed and built for tissue engineering. This design uses an integrated medium reservoir and flow chamber in order to increase the throughput, limit the volume of medium required to operate the system, and simplify the assembly and operation.
ISSN:1937-3384
1937-3392
DOI:10.1089/ten.tec.2012.0037